TY - JOUR
T1 - An experimental treatment of ocular quinine toxicity with high-dose 9-CIS beta-carotene
AU - Meshi, Amit
AU - Belkin, Avner
AU - Koval, Tal
AU - Kornhouser, Tom
AU - Assia, Ehud I.
AU - Rotenstreich, Ygal
N1 - Publisher Copyright:
Copyright © by Ophthalmic Communications Society, Inc.
PY - 2015/4/6
Y1 - 2015/4/6
N2 - Purpose: To report a case of severe ocular quinine toxicity after a suicide attempt and an experimental treatment with high-dose 9-cis beta-carotene. Methods: Interventional case report. Results: A 59-year-old woman presented with acute bilateral blindness after ingesting high dose (12 g) of quinine sulphate. Her vision was no light perception in either eye, and her pupils were fixed and middilated. Because of limited vision and poor prognosis, she was treated with an experimental rescue therapy of high-dose 9-cis beta-carotene Dunaliella bardawil powder for 3 months, starting 10 days postingestion. Electroretinography measurements showed transient improvement in a-wave amplitudes. The electroretinography b-wave showed only partial transient improvement in the left eye. Overall, the patient's visual acuity improved to 20/33 in the right eye and 20/40 in the left eye, but with extremely constricted visual fields. Conclusion: Transient improvement in electroretinography measurements was observed under treatment with high-dose 9-cis beta-carotene in ocular quinine toxicity, although no clinical benefit was documented. More research is needed to determine its effect in patients with toxic retinal damage.
AB - Purpose: To report a case of severe ocular quinine toxicity after a suicide attempt and an experimental treatment with high-dose 9-cis beta-carotene. Methods: Interventional case report. Results: A 59-year-old woman presented with acute bilateral blindness after ingesting high dose (12 g) of quinine sulphate. Her vision was no light perception in either eye, and her pupils were fixed and middilated. Because of limited vision and poor prognosis, she was treated with an experimental rescue therapy of high-dose 9-cis beta-carotene Dunaliella bardawil powder for 3 months, starting 10 days postingestion. Electroretinography measurements showed transient improvement in a-wave amplitudes. The electroretinography b-wave showed only partial transient improvement in the left eye. Overall, the patient's visual acuity improved to 20/33 in the right eye and 20/40 in the left eye, but with extremely constricted visual fields. Conclusion: Transient improvement in electroretinography measurements was observed under treatment with high-dose 9-cis beta-carotene in ocular quinine toxicity, although no clinical benefit was documented. More research is needed to determine its effect in patients with toxic retinal damage.
KW - 9-cis beta-carotene
KW - ocular quinine toxicity
KW - rescue therapy
UR - http://www.scopus.com/inward/record.url?scp=84926302782&partnerID=8YFLogxK
U2 - 10.1097/ICB.0000000000000125
DO - 10.1097/ICB.0000000000000125
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C2 - 25545373
AN - SCOPUS:84926302782
VL - 9
SP - 157
EP - 161
JO - Retinal Cases and Brief Reports
JF - Retinal Cases and Brief Reports
SN - 1935-1089
IS - 2
ER -
