An evolutionary perspective on complex neuropsychiatric disease

Jon M. McClellan; Anthony W. Zoghbi; Joseph D. Buxbaum; Carolina Cappi; James J. Crowley; Jonathan Flint; Dorothy E. Grice; Suleyman Gulsuner; Conrad Iyegbe; Sanjeev Jain; Po Hsiu Kuo; Maria Claudia Lattig; Maria Rita Passos-Bueno; Meera Purushottam; Dan J. Stein; Anna B. Sunshine; Ezra S. Susser; Christopher A. Walsh; Olivia Wootton; Mary Claire King

doi:10.1016/j.neuron.2023.10.037

An evolutionary perspective on complex neuropsychiatric disease

Jon M. McClellan, Anthony W. Zoghbi, Joseph D. Buxbaum, Carolina Cappi, James J. Crowley, Jonathan Flint, Dorothy E. Grice, Suleyman Gulsuner, Conrad Iyegbe, Sanjeev Jain, Po Hsiu Kuo, Maria Claudia Lattig, Maria Rita Passos-Bueno, Meera Purushottam, Dan J. Stein, Anna B. Sunshine, Ezra S. Susser, Christopher A. Walsh, Olivia Wootton, Mary Claire King^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere. Understanding the genetic causes of neuropsychiatric disease in the widest possible range of human populations thus yields the greatest possible range of insight into genes critical to human brain development. In this perspective, we explore some of the relationships between genes, adaptation, and history that can be illuminated by an evolutionary perspective on studies of complex neuropsychiatric disease in diverse populations.

Original language	English
Pages (from-to)	7-24
Number of pages	18
Journal	Neuron
Volume	112
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2023.10.037
State	Published - 3 Jan 2024
Externally published	Yes

Keywords

22q11 deletion
assortative mating
autism
bipolar disorder
causality
clinical heterogeneity
complex neuropsychiatric disease
consanguinity
de novo mutation
evolution
genetic drift
genetics
genomics
migration
OCD
polygenic inheritance
rare alleles
schizophrenia
selection
somatic mutation

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10.1016/j.neuron.2023.10.037

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McClellan, J. M., Zoghbi, A. W., Buxbaum, J. D., Cappi, C., Crowley, J. J., Flint, J., Grice, D. E., Gulsuner, S., Iyegbe, C., Jain, S., Kuo, P. H., Lattig, M. C., Passos-Bueno, M. R., Purushottam, M., Stein, D. J., Sunshine, A. B., Susser, E. S., Walsh, C. A., Wootton, O., & King, M. C. (2024). An evolutionary perspective on complex neuropsychiatric disease. Neuron, 112(1), 7-24. https://doi.org/10.1016/j.neuron.2023.10.037

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abstract = "The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere. Understanding the genetic causes of neuropsychiatric disease in the widest possible range of human populations thus yields the greatest possible range of insight into genes critical to human brain development. In this perspective, we explore some of the relationships between genes, adaptation, and history that can be illuminated by an evolutionary perspective on studies of complex neuropsychiatric disease in diverse populations.",

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author = "McClellan, {Jon M.} and Zoghbi, {Anthony W.} and Buxbaum, {Joseph D.} and Carolina Cappi and Crowley, {James J.} and Jonathan Flint and Grice, {Dorothy E.} and Suleyman Gulsuner and Conrad Iyegbe and Sanjeev Jain and Kuo, {Po Hsiu} and Lattig, {Maria Claudia} and Passos-Bueno, {Maria Rita} and Meera Purushottam and Stein, {Dan J.} and Sunshine, {Anna B.} and Susser, {Ezra S.} and Walsh, {Christopher A.} and Olivia Wootton and King, {Mary Claire}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2024",

month = jan,

day = "3",

doi = "10.1016/j.neuron.2023.10.037",

language = "אנגלית",

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McClellan, JM, Zoghbi, AW, Buxbaum, JD, Cappi, C, Crowley, JJ, Flint, J, Grice, DE, Gulsuner, S, Iyegbe, C, Jain, S, Kuo, PH, Lattig, MC, Passos-Bueno, MR, Purushottam, M, Stein, DJ, Sunshine, AB, Susser, ES, Walsh, CA, Wootton, O & King, MC 2024, 'An evolutionary perspective on complex neuropsychiatric disease', Neuron, vol. 112, no. 1, pp. 7-24. https://doi.org/10.1016/j.neuron.2023.10.037

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AU - McClellan, Jon M.

AU - Zoghbi, Anthony W.

AU - Buxbaum, Joseph D.

AU - Cappi, Carolina

AU - Crowley, James J.

AU - Flint, Jonathan

AU - Grice, Dorothy E.

AU - Gulsuner, Suleyman

AU - Iyegbe, Conrad

AU - Jain, Sanjeev

AU - Kuo, Po Hsiu

AU - Lattig, Maria Claudia

AU - Passos-Bueno, Maria Rita

AU - Purushottam, Meera

AU - Stein, Dan J.

AU - Sunshine, Anna B.

AU - Susser, Ezra S.

AU - Walsh, Christopher A.

AU - Wootton, Olivia

AU - King, Mary Claire

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N2 - The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere. Understanding the genetic causes of neuropsychiatric disease in the widest possible range of human populations thus yields the greatest possible range of insight into genes critical to human brain development. In this perspective, we explore some of the relationships between genes, adaptation, and history that can be illuminated by an evolutionary perspective on studies of complex neuropsychiatric disease in diverse populations.

AB - The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere. Understanding the genetic causes of neuropsychiatric disease in the widest possible range of human populations thus yields the greatest possible range of insight into genes critical to human brain development. In this perspective, we explore some of the relationships between genes, adaptation, and history that can be illuminated by an evolutionary perspective on studies of complex neuropsychiatric disease in diverse populations.

KW - 22q11 deletion

KW - assortative mating

KW - autism

KW - bipolar disorder

KW - causality

KW - clinical heterogeneity

KW - complex neuropsychiatric disease

KW - consanguinity

KW - de novo mutation

KW - evolution

KW - genetic drift

KW - genetics

KW - genomics

KW - migration

KW - OCD

KW - polygenic inheritance

KW - rare alleles

KW - schizophrenia

KW - selection

KW - somatic mutation

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AN - SCOPUS:85180609371

SN - 0896-6273

VL - 112

SP - 7

EP - 24

JO - Neuron

JF - Neuron

IS - 1

ER -

An evolutionary perspective on complex neuropsychiatric disease

Abstract

Keywords

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