An evolutionary perspective of animal microRNAs and their targets

Noam Shomron*, David Golan, Eran Hornstein

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting 50 of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs.

Original languageEnglish
Article number594738
JournalJournal of Biomedicine and Biotechnology
StatePublished - 2009


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