An Escherichia coli gene responsive to heavy metals

Reuven Babai, Eliora Z. Ron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Using in vivo translational gene fusion in Escherichia coli K-12 we identified a gene that is specifically induced by heavy metals, cadmium, mercury and zinc, at nmolar concentrations. This gene was identified by homology to known zinc and cadmium transporters. We created a disruption of the gene that resulted only in a minor increase in sensitivity to cadmium, suggesting that the fusion, which is at the carboxy-terminal end of the molecule, probably allows for at least partial activity of the protein. Copyright (C) 1998 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalFEMS Microbiology Letters
Issue number2
StatePublished - 15 Oct 1998


  • Cadmium
  • Gene regulation
  • Heavy metal
  • Mercury
  • Stress response
  • Zinc


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