TY - JOUR
T1 - An epidemiological analysis of osteoporotic characteristics in patients affected with rheumatoid arthritis in Kazakhstan
AU - Gabdulina, Gulzhan
AU - Kasher, Melody
AU - Beissebayeva, Aliya
AU - Mussabaeva, Dana
AU - Tokarev, Alexander
AU - Mominova, Gulmira
AU - Essirkepova, Gulnar
AU - Amanzholova, Ainash
AU - Zaurbekova, Korlan
AU - Saparbaeva, Maira
AU - Bizhanova, Maira
AU - Kulshymanova, Moldir
AU - Livshits, Gregory
N1 - Publisher Copyright:
© 2018, International Osteoporosis Foundation and National Osteoporosis Foundation.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Purpose: We aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan. Methods: Four hundred six RA patients (90.6% females) with 397 controls—unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN), and US_T-scores. Results: In the RA affected female population, ~ 80% suffered from osteopenia or osteoporosis. All OP-RP were negatively correlated with age and female’s sex, as expected, and thus accordingly adjusted, resulting in consistent, significantly [p = 0.016 (CI), p < 0.0001 (both BMDSPN and US_T-scores)] lower OP-RP estimates in affected females. Using multiple regression analysis for OP-RP manifestations, only age and disease duration appeared consistently associated with all three studied phenotypes, while menopause status or years following the onset of menopause were also significant for BMDSPN and US_T-scores. However, when disease duration was examined, we found that it was significantly dependent on morning stiffness, ESR, total cholesterol levels, weight, and menopause status, which explains 38.6% of the disease duration. Conclusions: Approximately 80% of female RA patients suffer from osteoporosis or osteopenia in the study group, which appears from a young age. RA disease duration is the major risk factor for OP-RP deterioration, especially as assessed by BMDSPNG, and US_T-scores. As a result, all OP-RP demonstrate significantly lower levels in comparison to sex- and age-matched unaffected individuals.
AB - Purpose: We aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan. Methods: Four hundred six RA patients (90.6% females) with 397 controls—unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN), and US_T-scores. Results: In the RA affected female population, ~ 80% suffered from osteopenia or osteoporosis. All OP-RP were negatively correlated with age and female’s sex, as expected, and thus accordingly adjusted, resulting in consistent, significantly [p = 0.016 (CI), p < 0.0001 (both BMDSPN and US_T-scores)] lower OP-RP estimates in affected females. Using multiple regression analysis for OP-RP manifestations, only age and disease duration appeared consistently associated with all three studied phenotypes, while menopause status or years following the onset of menopause were also significant for BMDSPN and US_T-scores. However, when disease duration was examined, we found that it was significantly dependent on morning stiffness, ESR, total cholesterol levels, weight, and menopause status, which explains 38.6% of the disease duration. Conclusions: Approximately 80% of female RA patients suffer from osteoporosis or osteopenia in the study group, which appears from a young age. RA disease duration is the major risk factor for OP-RP deterioration, especially as assessed by BMDSPNG, and US_T-scores. As a result, all OP-RP demonstrate significantly lower levels in comparison to sex- and age-matched unaffected individuals.
KW - Bone mineral density (BMD)
KW - Cortical index
KW - Osteoporosis
KW - Rheumatoid arthritis
KW - Risk factors
KW - US_T-score
UR - http://www.scopus.com/inward/record.url?scp=85053628994&partnerID=8YFLogxK
U2 - 10.1007/s11657-018-0514-9
DO - 10.1007/s11657-018-0514-9
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AN - SCOPUS:85053628994
SN - 1862-3522
VL - 13
JO - Archives of Osteoporosis
JF - Archives of Osteoporosis
IS - 1
M1 - 99
ER -