An atomistic view of rigid crystalline supramolecular polymers derived from short amphiphilic, α,β hybrid peptide

Rajkumar Misra, Francesca Netti, Gil Koren, Yoav Dan, Priyadarshi Chakraborty, Sidney R. Cohen, Linda J.W. Shimon, Roy Beck, Lihi Adler-Abramovich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Peptide amphiphiles exhibit excellent self-assembly properties and have potential applications ranging from materials science to nanobiotechnology. Yet, a detailed understanding of supramolecular assembly from an atomistic perspective is still lacking. Here, we demonstrate the spontaneous self-association of an aromatic amphiphilic α,β-hybrid into a hierarchically-oriented crystalline supramolecular polymer under aqueous conditions. Single-crystal analysis after fiber recrystallization revealed that the peptide formed a β-sheet structure stabilized by intermolecular hydrogen bonds and aromatic-aromatic interactions. The head-to-head salt bridge interaction between the opposite charges and hydrogen bonding between the strands account for the elongated shape of the crystal and for the high mechanical strength of the fibers. A new composite biocompatible hydrogel was further fabricated by co-assembly of the hybrid peptide with a well-established hydrogelator. These findings shed light on molecular-level understanding of the supramolecular assembly of hybrid peptide amphiphiles, facilitating development of new composite hydrogels for various applications.

Original languageEnglish
JournalPolymer Chemistry
Issue number12
StatePublished - 24 Oct 2022


FundersFunder number
Horizon 2020 Framework Programme
European Research Council
Department of Science and Technology, Ministry of Science and Technology, IndiaDST/INSPIRE/04/2020/002499
Ministry of Science, Technology and Space
Israel Science Foundation1454/19, 2185/17
Horizon 2020948102


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