An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival

E. Ben-Hurl; R. Koll; Y. M. Heimerl; Y. Shiloh; E. Tabor; Y. Becker

doi:10.1007/BF01323923

An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival

E. Ben-Hurl^*, R. Koll, Y. M. Heimerl, Y. Shiloh, E. Tabor, Y. Becker

^*Corresponding author for this work

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Abstract

Exposure of normal human fibroblasts (F107) in stationary phase to γ radiation inhibited the appearance of induced ornithine decarboxylase (ODC) activity. Skin fibroblasts derived from two ataxia telangiectasia (AT) patients (F184 and F182) displayed a similar response. The level of DNA repair synthesis was also similar in the three cell strains. Fibroblasts from another apparently normal donor (F196) were very sensitive to inhibition of induced ODC activity by γ radiation and were also deficient in radiation-induced DNA repair synthesis. However, the two strains derived from normal donors displayed the same degree of cellular sensitivity towards X-rays, whereas the two AT strains showed the typical hypersensitivity to the cytotoxic effect of X-irradiation. The results suggest a possible correlation between the inhibition of induced ODC activity by γ radiation and the extent of DNA repair synthesis at high radiation doses, but there is no correlation between these two parameters and cellular survival at low radiation doses.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Radiation and Environmental Biophysics
Volume	20
Issue number	1
DOIs	https://doi.org/10.1007/BF01323923
State	Published - Mar 1981
Externally published	Yes

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Ben-Hurl, E., Koll, R., Heimerl, Y. M., Shiloh, Y., Tabor, E., & Becker, Y. (1981). An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival. Radiation and Environmental Biophysics, 20(1), 21-28. https://doi.org/10.1007/BF01323923

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title = "An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival",

abstract = "Exposure of normal human fibroblasts (F107) in stationary phase to γ radiation inhibited the appearance of induced ornithine decarboxylase (ODC) activity. Skin fibroblasts derived from two ataxia telangiectasia (AT) patients (F184 and F182) displayed a similar response. The level of DNA repair synthesis was also similar in the three cell strains. Fibroblasts from another apparently normal donor (F196) were very sensitive to inhibition of induced ODC activity by γ radiation and were also deficient in radiation-induced DNA repair synthesis. However, the two strains derived from normal donors displayed the same degree of cellular sensitivity towards X-rays, whereas the two AT strains showed the typical hypersensitivity to the cytotoxic effect of X-irradiation. The results suggest a possible correlation between the inhibition of induced ODC activity by γ radiation and the extent of DNA repair synthesis at high radiation doses, but there is no correlation between these two parameters and cellular survival at low radiation doses.",

author = "E. Ben-Hurl and R. Koll and Heimerl, {Y. M.} and Y. Shiloh and E. Tabor and Y. Becker",

year = "1981",

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Ben-Hurl, E, Koll, R, Heimerl, YM, Shiloh, Y, Tabor, E & Becker, Y 1981, 'An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival', Radiation and Environmental Biophysics, vol. 20, no. 1, pp. 21-28. https://doi.org/10.1007/BF01323923

An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival. / Ben-Hurl, E.; Koll, R.; Heimerl, Y. M. et al.
In: Radiation and Environmental Biophysics, Vol. 20, No. 1, 03.1981, p. 21-28.

Research output: Contribution to journal › Article › peer-review

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AB - Exposure of normal human fibroblasts (F107) in stationary phase to γ radiation inhibited the appearance of induced ornithine decarboxylase (ODC) activity. Skin fibroblasts derived from two ataxia telangiectasia (AT) patients (F184 and F182) displayed a similar response. The level of DNA repair synthesis was also similar in the three cell strains. Fibroblasts from another apparently normal donor (F196) were very sensitive to inhibition of induced ODC activity by γ radiation and were also deficient in radiation-induced DNA repair synthesis. However, the two strains derived from normal donors displayed the same degree of cellular sensitivity towards X-rays, whereas the two AT strains showed the typical hypersensitivity to the cytotoxic effect of X-irradiation. The results suggest a possible correlation between the inhibition of induced ODC activity by γ radiation and the extent of DNA repair synthesis at high radiation doses, but there is no correlation between these two parameters and cellular survival at low radiation doses.

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Ben-Hurl E, Koll R, Heimerl YM, Shiloh Y, Tabor E, Becker Y. An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival. Radiation and Environmental Biophysics. 1981 Mar;20(1):21-28. doi: 10.1007/BF01323923

An apparent correlation between the inhibition of induced ornithine decarboxylase activity by γ radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: No correlation with cell survival

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