An "aggressive" protocol of programmed ventricular stimulation for selecting post-myocardial infarction patients with a low ejection fraction who may not require implantation of an automatic defibrillator

Bernard Belhassen*, Tamar Ohayon-Tsioni, Aharon Glick, Sami Viskin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The predictive value of electrophysiologic studies depends on the aggressiveness of the programmed ventricular stimulation protocol. Objectives: To assess if non-inducibility with an "aggressive" protocol of PVS identifies post-infarction patients with low ejection fraction (EF ≤ 30%) who may safely be treated without implantable cardioverter defibrillator. Methods: We studied 154 patients during a 9 year period. Our aggressive PVS protocol included: a) stimulus current five times the diastolic threshold (≤ 3 mA) and b) repetition of double and triple extrastimulation at the shortest coupling intervals that capture the ventricle. Results: Sustained ventricular tachyarrhythmias were induced in 116 patients (75.4%) and 112 (97%) of them received an ICD (EPS+/ICD+ group). Of the 38 non-inducible patients, 34 (89.5%) did not receive an ICD (EPS-/ICD-group). In comparison to the EPS+/ICD+ group, EPS-/ICDgroup patients were older (69 ± 10 vs. 65 ± 10 years, P < 0.05), had a lower EF (23 ± 5% vs. 25 ± 5%, P < 0.05) and a higher prevalence of left bundle branch block (45.5% vs. 20.2%, P < 0.005). Follow-up was longer for EPS+/ICD+ patients (40 ± 26 months) than for EPS-/ICD- patients (27 ± 22 months) ( P = 0.011). Twelve EPS+/ICD+ patients (10.7%) and 5 EPS-/ICD-patients (14.7%) died during follow-up (P = 0.525). Kaplan-Meier survival curves did not show a significant difference between the two groups (P = 0.18). Conclusions: The mortality rate in patients without inducible VTAs using an aggressive PVS protocol and who did not undergo subsequent ICD implantation is not different from that of patients with inducible arrhythmias who received an ICD. Using this protocol, as many as one-fourth of primary prevention ICD implants could be spared without compromising patient prognosis.

Original languageEnglish
Pages (from-to)520-527
Number of pages8
JournalIsrael Medical Association Journal
Volume11
Issue number9
StatePublished - Sep 2009

Keywords

  • Ejection fraction
  • Implantable cardioverter defibrillator
  • Post-myocardial infarction
  • Programmed ventricular stimulation

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