Amyotrophic Lateral Sclerosis as a Spatiotemporal Mislocalization Disease: Location, Location, Location

Noga Gershoni-Emek, Michael Chein, Shani Gluska, Eran Perlson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Spatiotemporal localization of signals is a fundamental feature impacting cell survival and proper function. The cell needs to respond in an accurate manner in both space and time to both intra- and intercellular environment cues. The regulation of this comprehensive process involves the cytoskeleton and the trafficking machinery, as well as local protein synthesis and ligand-receptor mechanisms. Alterations in such mechanisms can lead to cell dysfunction and disease. Motor neurons that can extend over tens of centimeters are a classic example for the importance of such events. Changes in spatiotemporal localization mechanisms are thought to play a role in motor neuron degeneration that occurs in amyotrophic lateral sclerosis (ALS). In this review we will discuss these mechanisms and argue that possible misregulated factors can lead to motor neuron degeneration in ALS.

Original languageEnglish
Pages (from-to)23-71
Number of pages49
JournalInternational Review of Cell and Molecular Biology
StatePublished - 2015


  • ALS
  • Axonal transport
  • Local synthesis
  • Neurotrophic factors
  • Spatiotemporal localization


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