TY - JOUR
T1 - Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation
T2 - Proof-of-concept in borderline personality disorder
AU - Zopfs, Malte
AU - Jindrová, Miroslava
AU - Gurevitch, Guy
AU - Keynan, Jackob N.
AU - Hendler, Talma
AU - Baumeister, Sarah
AU - Aggensteiner, Pascal M.
AU - Cornelisse, Sven
AU - Brandeis, Daniel
AU - Schmahl, Christian
AU - Paret, Christian
N1 - Publisher Copyright:
© The Author(s), 2023. Published by Cambridge University Press.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Background The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods Study 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls. Results Study 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results. Conclusions Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated.
AB - Background The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods Study 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls. Results Study 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results. Conclusions Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated.
KW - EEG
KW - amygdala
KW - borderline personality disorder
KW - emotion regulation
KW - fMRI
KW - neurofeedback
KW - neuroimaging
KW - post-traumatic stress disorder
KW - psychopathology
UR - http://www.scopus.com/inward/record.url?scp=85181714300&partnerID=8YFLogxK
U2 - 10.1017/S0033291723003549
DO - 10.1017/S0033291723003549
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C2 - 38131344
AN - SCOPUS:85181714300
SN - 0033-2917
VL - 54
SP - 1651
EP - 1660
JO - Psychological Medicine
JF - Psychological Medicine
IS - 8
ER -