Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator

Fernando Patolsky, Eugenii Katz, Itamar Willner

Research output: Contribution to journalArticlepeer-review

Abstract

Making light work for DNA detection: Amplified DNA detection is accomplished by doxorubicin intercalated into double-stranded DNA assembled on Au-electrodes. Stimulated electrogenerated biochemiluminescence or biocatalyzed precipitation of an insoluble product amplify the DNA sensing that is being transduced by light emission (see picture; HRP = horseradish peroxidase) or Faradaic impedance spectroscopy, respectively.

Original languageEnglish
Pages (from-to)3398-3402
Number of pages5
JournalAngewandte Chemie - International Edition
Volume41
Issue number18
DOIs
StatePublished - 16 Sep 2002
Externally publishedYes

Keywords

  • Biosensors
  • DNA
  • DNA recognition
  • Electroluminescence
  • Impedance spectroscopy
  • Intercalations

Fingerprint

Dive into the research topics of 'Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator'. Together they form a unique fingerprint.

Cite this