Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats

T. Rosenthal; M. Shani; E. Peleg; M. Harnik

doi:10.1080/07435809009032998

Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats

T. Rosenthal^*, M. Shani, E. Peleg, M. Harnik

^*Corresponding author for this work

Clinical Departments

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Abstract

A combination of aldosterone (1 μ g) with either 18-OH-corticosterone (1μ g) or 18-OH-19-nor-corticosterone (1μ g) injected to adrenalectomized rats indicated an amplification of mineralocorticoid activity as expressed by Na/K ratio in urine. Without aldosterone their mineralocorticoid potency was negligible.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Endocrine Research
Volume	16
Issue number	2
DOIs	https://doi.org/10.1080/07435809009032998
State	Published - 1990

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author = "T. Rosenthal and M. Shani and E. Peleg and M. Harnik",

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AU - Peleg, E.

AU - Harnik, M.

PY - 1990

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Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats

Abstract

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