TY - JOUR
T1 - Amplification of dynamic chiral crown ether complexes during cyclic acetal formation
AU - Fuchs, Benzion
AU - Nelson, Alshakim
AU - Star, Alexander
AU - Stoddart, J. Fraser
AU - Vidal, Sébastien
PY - 2003/9/15
Y1 - 2003/9/15
N2 - The dynamic duo: A more than tenfold increase in the yield of the chiral macropolycyclic polyether containing two 2,6-disubstituted 1,3,5,7-cis-tetraoxadecalin systems was obtained under thermodynamic conditions from a dynamic combinatorial virtual library with templating cesium ions (> 95 % yield, see schematic representation) relative to kinetic syntheses (< 8 % yields in their macropolycyclization steps), even when the same template was used.
AB - The dynamic duo: A more than tenfold increase in the yield of the chiral macropolycyclic polyether containing two 2,6-disubstituted 1,3,5,7-cis-tetraoxadecalin systems was obtained under thermodynamic conditions from a dynamic combinatorial virtual library with templating cesium ions (> 95 % yield, see schematic representation) relative to kinetic syntheses (< 8 % yields in their macropolycyclization steps), even when the same template was used.
KW - Combinatorial chemistry
KW - Macrocycles
KW - Supramolecular chemistry
KW - Template synthesis
KW - Transacetalation
UR - http://www.scopus.com/inward/record.url?scp=0141522573&partnerID=8YFLogxK
U2 - 10.1002/anie.200351558
DO - 10.1002/anie.200351558
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C2 - 14502741
AN - SCOPUS:0141522573
SN - 1433-7851
VL - 42
SP - 4220
EP - 4224
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 35
ER -