@article{a64b32b3b3cf492d9fbdf40a33f22ec6,
title = "AMPA receptor binding and subunit mRNA expression in prefrontal cortex and striatum of elderly schizophrenics",
abstract = "The dopamine hypothesis of schizophrenia has recently evolved into a model of dysfunctional integration between cortical and subcortical dopaminergic activity. Anatomical data suggest that regional alterations in dopaminergic activity may be linked by means of the rich glutamatergic innervation of the striatum by corticostriatal projections, suggesting a potential role for glutamatergic dysfunction in schizophrenia. Although pharmacological data have implicated the NMDA subtype of glutamate receptor in this illness, disturbance in AMPA receptor expression could potentially lead to the NMDA receptor hypoactivity hypothesized in schizophrenia. To address this possibility, we examined AMPA receptor binding and subunit mRNA levels in prefrontal cortex and striatum of schizophrenics and matched controls. There were no significant differences in AMPA receptor binding or subunit mRNA levels in either prefrontal cortical or striatal regions of schizophrenics. Furthermore, AMPA receptor expression did not seem to be regulated by chronic antipsychotic drug exposure, when neuroleptic treated and drug-free schizophrenics were analyzed separately. These data do not support a role for altered AMPA receptor expression in cortex and striatum in schizophrenia. Copyright (C) 1998 American College of Neuropsychopharmacology.",
keywords = "Glutamate, In situ hybridization, NMDA, Postmortem, Receptor autoradiography",
author = "Healy, {Daniel J.} and Vahram Haroutunian and Peter Powchik and Michael Davidson and Davis, {Kenneth L.} and Watson, {Stanley J.} and Meador-Woodruff, {James H.}",
note = "Funding Information: This work was supported in part by grant MH53327 and an award from the Stanley Foundation (J.H.M-W), a Veterans Administration Merit Review Award (VH), grants MH45212, AG5138, and AG2219 (KLD), and MH42251 (SJW). Dr. Healy was supported by MH15794 and an APA/Lilly Psychiatric Fellowship. Additional support was provided by the Department of Psychiatry and the Mental Health Research Institute at the University of Michigan. The authors appreciate the technical assistance of Scott P. Damsk, Jingcheng Wang, and Lisa Bain.",
year = "1998",
month = oct,
doi = "10.1016/S0893-133X(98)00014-1",
language = "אנגלית",
volume = "19",
pages = "278--286",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Springer Nature",
number = "4",
}