Amantadine antagonism of oxotremorine effects

Y. Eshel*, A. D. Korczyn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Administration of oxotremorine to mice produced centrally-mediated effects, such as catalepsy and tremor, and peripheral muscarinic actions, such as diarrhoea and lachrymation. Pretreatment with amantadine (25-200 mg/kg) prevented these oxotremorine-induced effects in mice. Catalepsy was most susceptible and tremor most resistant to the administration of amantadine. The possible mechanisms involved are discussed. Our results validate the use of the oxotremorine model in the search for novel antiparkinsonian drugs.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of Neural Transmission
Issue number1
StatePublished - Mar 1979


  • Oxotremorine
  • amantadine
  • catalepsy
  • dopamine-acetylcholine balance
  • extrapyramidal system
  • parkinsonism


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