Altered properties of erythrocytes in the aged

Nechama S. Kosower*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Erythrocytes in the aged have a decreased life span. The properties of the red blood cells of old individuals are compared to those of the cells of young individuals. In young individuals, removal of the normal erythrocyte at the end of its lifespan is determined by a signal(s) due to (1) modified phospholipids, (2) modified carbohydrate residues, and/or (3) modified proteins. Similar changes may occur in the erythrocytes of old individuals but at a greater rate. In particular, the enhanced degradation of band 3 protein by calpain may provide a senescence signal. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalAmerican Journal of Hematology
Volume42
Issue number3
DOIs
StatePublished - Mar 1993

Keywords

  • band 3 protein
  • calpain
  • red blood cells
  • senescence

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