Altered gene transcription following brief episodes of coronary occlusions

R. Knoll, R. Zimmermann, W. Schaper*, R. Reneman, B. O'Rourke, M. Lab, G. Kessler- Icekson, W. Barry, M. Parmacek, H. E.D.J. Ter Keurs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This study was designed to elucidate whether previously observed enhanced mRNAs were due to accelerated transcription, enhanced mRNA stability or both mechanisms. We employed the nuclear run-on technique on myocardial nuclei and found the transcriptional induction of several genes, especially nuclear protooncogenes, Ca2+ regulating and heat shock protein genes.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1995
Externally publishedYes


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