Altered antioxidant status in schizophrenic patients and the beneficial effect of treatment with Vitamin E

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Abstract

Background: Oxidative stress and autoimmunity are implicated in the etiology of schizophrenia. Findings on involvement of reactive oxygen species in schizophrenic patients included increased lipid peroxides and breath pentane and alterations in blood levels of antioxidant enzymes. There are reports on antioxidant treatments of schizophrenic patients, but they yielded conflicting results with regard to clinical improvements. Objective: Our study was aimed to reassess the antioxidant status of schizophrenic patients and the efficacy of treat ment with vitamin E. Methods: The sample was 40 hospitalized schizophrenic patients diagnosed with DSM-IV criteria and 37 healthy controls. Vitamin E treatment consisted of a doubleblind, placebo-controlled parallel-group design of vitamin E given as 200 i.u., b.i.d. for 6 weeks. Patients were randomly assigned to receive either active vitamin E (20 patients) or sesame oil placebo (20 patients) gelcaps. All patients received haloperidol. Results: Blood levels of glutathione transferase and catalase were significantly higher (131.6% and 127.3%, respectively p<0.01) in schizophrenic patients. CuZriSOD was higher ( 123%, p<0.01) while there was small, not significant decrease of MnSOD. Activity of glutathione reductase was 113% higher (not significant) in schizophrenic patients, when! all patients were compared to controls. However,'when'compared by gender, schizophrenic males had significantly higher activity'(131%, p0.05) relative to healthy controls. The activity ratio male: female Was 112% (not significant) in controls, and 135% (p=0.028) in schizophrenic patients. Blood TBARS , in schizophrenic patients was similar to that of healthy controls and GSH levels were 125% higher in patients (p0.05). . ., Conclusions: Treatment with vitamin E (but not with placebo) caused a significant decrease in blood activity of glutathione transferase and glutathione reduetase. There' was a positive correlation between the changes in the clinical and biochemical parameters:.

Original languageEnglish
Pages (from-to)135-136
Number of pages2
JournalIsrael Journal of Psychiatry and Related Sciences
Volume36
Issue number2
StatePublished - 1999

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