Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression

Gil Zalsman; Moshe Rehavi; Netta Roz; Nathaniel Laor; Abraham Weizman; Paz Toren

doi:10.1007/s00702-011-0643-4

Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression

Gil Zalsman^*, Moshe Rehavi, Netta Roz, Nathaniel Laor, Abraham Weizman, Paz Toren

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Platelet vesicular monoamine transporter (VMAT2) binding characteristics were assessed, using high affinity dihydrotetrabenazine ([ ³H]TBZOH) binding, in 14 children with major depression (MDD) and 16 matched controls. All participants underwent a thorough diagnostic evaluation and the levels of depression and anxiety were measured. K _d values were significantly lower in children with MDD versus controls (2.93 ± 0.84 vs. 3.63 ± 0.56 nM, respectively, t = 2.4, df = 18.4, p = 0.025). B _max values did not differ significantly. This preliminary finding indicates a possible structural change in platelet VMAT2 in children with MDD.

Original language	English
Pages (from-to)	1383-1387
Number of pages	5
Journal	Journal of Neural Transmission
Volume	118
Issue number	9
DOIs	https://doi.org/10.1007/s00702-011-0643-4
State	Published - Sep 2011

Funding

Funders	Funder number
Judie and Marshall Polk Research Fund for Children at Risk

Keywords

Adolescent
Children
Major depressive disorder
Platelet
Vesicular monoamine transporter

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10.1007/s00702-011-0643-4

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title = "Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression",

abstract = "Platelet vesicular monoamine transporter (VMAT2) binding characteristics were assessed, using high affinity dihydrotetrabenazine ([ 3H]TBZOH) binding, in 14 children with major depression (MDD) and 16 matched controls. All participants underwent a thorough diagnostic evaluation and the levels of depression and anxiety were measured. K d values were significantly lower in children with MDD versus controls (2.93 ± 0.84 vs. 3.63 ± 0.56 nM, respectively, t = 2.4, df = 18.4, p = 0.025). B max values did not differ significantly. This preliminary finding indicates a possible structural change in platelet VMAT2 in children with MDD.",

keywords = "Adolescent, Children, Major depressive disorder, Platelet, Vesicular monoamine transporter",

author = "Gil Zalsman and Moshe Rehavi and Netta Roz and Nathaniel Laor and Abraham Weizman and Paz Toren",

note = "Funding Information: The authors thank Michaella Gerchak for scientific and English editing. This study was partially supported by the Judie and Marshall Polk Research Fund for Children at Risk.",

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doi = "10.1007/s00702-011-0643-4",

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AU - Zalsman, Gil

AU - Rehavi, Moshe

AU - Roz, Netta

AU - Laor, Nathaniel

AU - Weizman, Abraham

AU - Toren, Paz

N1 - Funding Information: The authors thank Michaella Gerchak for scientific and English editing. This study was partially supported by the Judie and Marshall Polk Research Fund for Children at Risk.

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N2 - Platelet vesicular monoamine transporter (VMAT2) binding characteristics were assessed, using high affinity dihydrotetrabenazine ([ 3H]TBZOH) binding, in 14 children with major depression (MDD) and 16 matched controls. All participants underwent a thorough diagnostic evaluation and the levels of depression and anxiety were measured. K d values were significantly lower in children with MDD versus controls (2.93 ± 0.84 vs. 3.63 ± 0.56 nM, respectively, t = 2.4, df = 18.4, p = 0.025). B max values did not differ significantly. This preliminary finding indicates a possible structural change in platelet VMAT2 in children with MDD.

AB - Platelet vesicular monoamine transporter (VMAT2) binding characteristics were assessed, using high affinity dihydrotetrabenazine ([ 3H]TBZOH) binding, in 14 children with major depression (MDD) and 16 matched controls. All participants underwent a thorough diagnostic evaluation and the levels of depression and anxiety were measured. K d values were significantly lower in children with MDD versus controls (2.93 ± 0.84 vs. 3.63 ± 0.56 nM, respectively, t = 2.4, df = 18.4, p = 0.025). B max values did not differ significantly. This preliminary finding indicates a possible structural change in platelet VMAT2 in children with MDD.

KW - Adolescent

KW - Children

KW - Major depressive disorder

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Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression

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