Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression

Gil Zalsman*, Moshe Rehavi, Netta Roz, Nathaniel Laor, Abraham Weizman, Paz Toren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet vesicular monoamine transporter (VMAT2) binding characteristics were assessed, using high affinity dihydrotetrabenazine ([ 3H]TBZOH) binding, in 14 children with major depression (MDD) and 16 matched controls. All participants underwent a thorough diagnostic evaluation and the levels of depression and anxiety were measured. K d values were significantly lower in children with MDD versus controls (2.93 ± 0.84 vs. 3.63 ± 0.56 nM, respectively, t = 2.4, df = 18.4, p = 0.025). B max values did not differ significantly. This preliminary finding indicates a possible structural change in platelet VMAT2 in children with MDD.

Original languageEnglish
Pages (from-to)1383-1387
Number of pages5
JournalJournal of Neural Transmission
Volume118
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Adolescent
  • Children
  • Major depressive disorder
  • Platelet
  • Vesicular monoamine transporter

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