Alterations in QT dispersion in the surface electrocardiogram of female adolescents diagnosed with restricting-type anorexia nervosa

Eitan Nahshoni, Abraham Weizman, Amit Yaroslavsky, Anat Toledano, Jacqueline Sulkes, Daniel Stein

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: QT dispersion (QTd), defined as the difference between the longest interval and the shortest interval in the 12-lead electrocardiogram (ECG), is a measure of myocardial repolarization inhomogeneity. We assessed QTd in malnourished anorexia nervosa (AN) inpatients and following weight restoration. Methods: QTd analysis, anthropometric evaluations, and laboratory tests were carried out in 30 malnourished female adolescent AN restricting-type (AN-R) inpatients and following weight restoration. Results: A significant increase was found in weight/height ratio and body mass index from malnourished stage to weight restoration, paralleled by a significant decrease in QTd (70±16 vs. 47±16 ms; P<.0001). No correlations were found between ECG indices and anthropometric and laboratory measures. Conclusion: Elevated QTd in malnourished AN-R inpatients may indicate possible cardiac autonomic imbalance and/or myocardial damage, likely corrected following weight restoration.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalJournal of Psychosomatic Research
Volume62
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Anorexia nervosa
  • Autonomic nervous system
  • Eating disorders
  • Electrocardiogram
  • QT dispersion

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