Alterations in QT dispersion in medicated schizophrenia patients following electroconvulsive therapy

Eitan Nahshoni, Nira Manor, Faina Bar, Rafael Stryjer, Gil Zalsman, Abaraham Weizman

Research output: Contribution to journalArticlepeer-review

Abstract

QT dispersion (QTd) is a measure of interlead variations of the surface 12-lead electrocardiogram (ECG). Increased QTd, found in various cardiac diseases, reflects cardiac instability and is associated with increased risk for cardiac death. Research suggests a link between antipsychotics, ECG abnormalities (QT prolongation) and increased sudden cardiac mortality rates. However, QTd analysis has been scarcely investigated in schizophrenia patients. We calculated QTd in 20 medicated psychotic inpatients with schizophrenia, before and 3 days after electroconvulsive therapy (ECT), concomitantly with Brief Psychiatric Rating Scale (BPRS) assessment. QT interval and the rate-corrected QT (QTc) were abnormally prolonged before ECT. However, although QT was significantly shortened, QTc showed only a marginal decrease after ECT. QTd, the rate-corrected QTd, as well as BPRS, showed a significant decrease after ECT. Further large-scale studies are warranted to determine if QTd can serve as a marker for response to ECT, and if it is a risk factor for sudden cardiac death in schizophrenia patients.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalEuropean Neuropsychopharmacology
Volume14
Issue number2
DOIs
StatePublished - Mar 2004

Keywords

  • ECG
  • Electroconvulsive therapy
  • Heart
  • QT dispersion
  • QT interval
  • Schizophrenia

Fingerprint

Dive into the research topics of 'Alterations in QT dispersion in medicated schizophrenia patients following electroconvulsive therapy'. Together they form a unique fingerprint.

Cite this