ALSUntangled #64: butyrates

Yuyao Sun; Richard Bedlack; Carmel Armon; Morgan Beauchamp; Tulio Bertorini; Robert Bowser; Mark Bromberg; James Caress; Gregory Carter; Jesse Crayle; Merit E. Cudkowicz; Jonathan D. Glass; Carlayne Jackson; Isaac Lund; Sarah Martin; Sabrina Paganoni; Gary Pattee; Dylan Ratner; Kristiana Salmon; Paul Wicks

doi:10.1080/21678421.2022.2045323

ALSUntangled #64: butyrates

Yuyao Sun, Richard Bedlack^*, Carmel Armon, Morgan Beauchamp, Tulio Bertorini, Robert Bowser, Mark Bromberg, James Caress, Gregory Carter, Jesse Crayle, Merit E. Cudkowicz, Jonathan D. Glass, Carlayne Jackson, Isaac Lund, Sarah Martin, Sabrina Paganoni, Gary Pattee, Dylan Ratner, Kristiana Salmon, Paul Wicks

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.

Original language	English
Pages (from-to)	638-643
Number of pages	6
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume	23
Issue number	7-8
DOIs	https://doi.org/10.1080/21678421.2022.2045323
State	Published - 2022
Externally published	Yes

Funding

Funders	Funder number
GenieUs
Woolsey Pharma
ALS Association
Cytokinetics

Keywords

ALS
alternative therapy
butyrate
gut microbiome
neuroinflammation

Access to Document

10.1080/21678421.2022.2045323

Cite this

Sun, Y., Bedlack, R., Armon, C., Beauchamp, M., Bertorini, T., Bowser, R., Bromberg, M., Caress, J., Carter, G., Crayle, J., Cudkowicz, M. E., Glass, J. D., Jackson, C., Lund, I., Martin, S., Paganoni, S., Pattee, G., Ratner, D., Salmon, K., & Wicks, P. (2022). ALSUntangled #64: butyrates. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 23(7-8), 638-643. https://doi.org/10.1080/21678421.2022.2045323

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title = "ALSUntangled #64: butyrates",

abstract = "ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.",

keywords = "ALS, alternative therapy, butyrate, gut microbiome, neuroinflammation",

author = "Yuyao Sun and Richard Bedlack and Carmel Armon and Morgan Beauchamp and Tulio Bertorini and Robert Bowser and Mark Bromberg and James Caress and Gregory Carter and Jesse Crayle and Cudkowicz, {Merit E.} and Glass, {Jonathan D.} and Carlayne Jackson and Isaac Lund and Sarah Martin and Sabrina Paganoni and Gary Pattee and Dylan Ratner and Kristiana Salmon and Paul Wicks",

note = "Publisher Copyright: {\textcopyright} 2022 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.",

year = "2022",

doi = "10.1080/21678421.2022.2045323",

language = "אנגלית",

volume = "23",

pages = "638--643",

journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",

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Sun, Y, Bedlack, R, Armon, C, Beauchamp, M, Bertorini, T, Bowser, R, Bromberg, M, Caress, J, Carter, G, Crayle, J, Cudkowicz, ME, Glass, JD, Jackson, C, Lund, I, Martin, S, Paganoni, S, Pattee, G, Ratner, D, Salmon, K & Wicks, P 2022, 'ALSUntangled #64: butyrates', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 23, no. 7-8, pp. 638-643. https://doi.org/10.1080/21678421.2022.2045323

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AU - Sun, Yuyao

AU - Bedlack, Richard

AU - Armon, Carmel

AU - Beauchamp, Morgan

AU - Bertorini, Tulio

AU - Bowser, Robert

AU - Bromberg, Mark

AU - Caress, James

AU - Carter, Gregory

AU - Crayle, Jesse

AU - Cudkowicz, Merit E.

AU - Glass, Jonathan D.

AU - Jackson, Carlayne

AU - Lund, Isaac

AU - Martin, Sarah

AU - Paganoni, Sabrina

AU - Pattee, Gary

AU - Ratner, Dylan

AU - Salmon, Kristiana

AU - Wicks, Paul

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AB - ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.

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ALSUntangled #64: butyrates

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