TY - JOUR
T1 - Alpha globulin decreases resistance of mice to infection with group a streptococcus
AU - Glaser, Moshe
AU - Nelken, David
AU - Ofek, Itzhak
AU - Bergner-Rabinowitz, Sonia
AU - Ginsburg, Isaac
N1 - Funding Information:
Received for publication June 21, 1972, and in revised form October 11, 1972. This investigation was supported by -the Lil and Ben Stein Transplantation Foundation. Please address requests for reprints to Prof. David Nelken, Department of Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
PY - 1973/3
Y1 - 1973/3
N2 - An a-globulin fraction of normal human plasma increased the susceptibility of mice to infection with group A Streptococcus, suppressed the streptococcicidal activity of mouse blood, and inhibited formation of antibody to Streptococcus. These effects of the a-globulin were greatest when the protein was injected one day before bleeding the animals or bacterial challenge. These effects were dose dependent. The doses of a-globulin that significantly suppressed production of antibody to streptococci were ineffective in increasing the susceptibility of mice to infection and in depressing the bactericidal activity of the blood of mice. It is concluded that lymphocytes and macrophages are susceptible to different concentrations of a-globulin. A high incidence of myocardial, pericardial, and hepatic lesions was found in animals treated with a-globulin and challenged with streptococci, both virulent and non virulent for mice. Alpha globulin alone did not cause any similar effects. It is suggested that the depression of phagocytosis by a-globulin enhanced the proliferation of streptococci and allowed the in-vivo production of larger amounts of tissue-damaging toxins.
AB - An a-globulin fraction of normal human plasma increased the susceptibility of mice to infection with group A Streptococcus, suppressed the streptococcicidal activity of mouse blood, and inhibited formation of antibody to Streptococcus. These effects of the a-globulin were greatest when the protein was injected one day before bleeding the animals or bacterial challenge. These effects were dose dependent. The doses of a-globulin that significantly suppressed production of antibody to streptococci were ineffective in increasing the susceptibility of mice to infection and in depressing the bactericidal activity of the blood of mice. It is concluded that lymphocytes and macrophages are susceptible to different concentrations of a-globulin. A high incidence of myocardial, pericardial, and hepatic lesions was found in animals treated with a-globulin and challenged with streptococci, both virulent and non virulent for mice. Alpha globulin alone did not cause any similar effects. It is suggested that the depression of phagocytosis by a-globulin enhanced the proliferation of streptococci and allowed the in-vivo production of larger amounts of tissue-damaging toxins.
UR - http://www.scopus.com/inward/record.url?scp=0015592975&partnerID=8YFLogxK
U2 - 10.1093/infdis/127.3.303
DO - 10.1093/infdis/127.3.303
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C2 - 4120227
AN - SCOPUS:0015592975
SN - 0022-1899
VL - 127
SP - 303
EP - 306
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -