Allostery modulates the beat rate of a cardiac pacemaker

Chung Jung Tsai, Ruth Nussinov*, Norma Allewell

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes.

Original languageEnglish
Pages (from-to)6429-6430
Number of pages2
JournalJournal of Biological Chemistry
Issue number15
StatePublished - 14 Apr 2017


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