@article{7dd081b2360540a493f1cbbb5fbf6401,
title = "Allostery modulates the beat rate of a cardiac pacemaker",
abstract = "The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes.",
author = "Tsai, {Chung Jung} and Ruth Nussinov and Norma Allewell",
note = "Funding Information: This work was supported, in whole or in part, by NCI, National Institutes of Health, Contract No. HHSN261200800001E. This work was supported in part by the Intramural Research Program of the NCI, National Institutes of Health, Center for Cancer Research. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. The authors declare that they have no conflicts of interest with the contents of this article.",
year = "2017",
month = apr,
day = "14",
doi = "10.1074/jbc.H116.773697",
language = "אנגלית",
volume = "292",
pages = "6429--6430",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "15",
}