TY - JOUR
T1 - Allostery in disease and in drug discovery
AU - Nussinov, Ruth
AU - Tsai, Chung Jung
N1 - Funding Information:
This project has been funded in whole or in part with Federal funds from the NCI, NIH, under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of DHHS, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported in part by the Intramural Research Program of the NIH, NCI, CCR.
PY - 2013/4/11
Y1 - 2013/4/11
N2 - Allostery is largely associated with conformational and functional transitions in individual proteins. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. Here, we clarify the concept of allostery and how it controls physiological activities. We focus on the challenging questions of how allostery can both cause disease and contribute to development of new therapeutics. We aim to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level and to emphasize the potential of allosteric drugs in innovative therapies.
AB - Allostery is largely associated with conformational and functional transitions in individual proteins. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. Here, we clarify the concept of allostery and how it controls physiological activities. We focus on the challenging questions of how allostery can both cause disease and contribute to development of new therapeutics. We aim to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level and to emphasize the potential of allosteric drugs in innovative therapies.
UR - http://www.scopus.com/inward/record.url?scp=84876266689&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2013.03.034
DO - 10.1016/j.cell.2013.03.034
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AN - SCOPUS:84876266689
SN - 0092-8674
VL - 153
SP - 293
EP - 305
JO - Cell
JF - Cell
IS - 2
ER -
