Allostery in disease and in drug discovery

Ruth Nussinov; Chung Jung Tsai

doi:10.1016/j.cell.2013.03.034

Allostery in disease and in drug discovery

Ruth Nussinov^*, Chung Jung Tsai

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

SAIC

Research output: Contribution to journal › Review article › peer-review

581 Scopus citations

Abstract

Allostery is largely associated with conformational and functional transitions in individual proteins. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. Here, we clarify the concept of allostery and how it controls physiological activities. We focus on the challenging questions of how allostery can both cause disease and contribute to development of new therapeutics. We aim to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level and to emphasize the potential of allosteric drugs in innovative therapies.

Original language	English
Pages (from-to)	293-305
Number of pages	13
Journal	Cell
Volume	153
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2013.03.034
State	Published - 11 Apr 2013

Funding

Funders	Funder number
National Institutes of Health	HHSN261200800001E
National Cancer Institute	ZIABC010440

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2013.03.034

Cite this

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abstract = "Allostery is largely associated with conformational and functional transitions in individual proteins. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. Here, we clarify the concept of allostery and how it controls physiological activities. We focus on the challenging questions of how allostery can both cause disease and contribute to development of new therapeutics. We aim to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level and to emphasize the potential of allosteric drugs in innovative therapies.",

author = "Ruth Nussinov and Tsai, {Chung Jung}",

note = "Funding Information: This project has been funded in whole or in part with Federal funds from the NCI, NIH, under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of DHHS, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported in part by the Intramural Research Program of the NIH, NCI, CCR.",

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Allostery in disease and in drug discovery

Abstract

Funding

UN SDGs

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