Allosteric regulation of autoinhibition and activation of c-Abl

Medicine & Life Sciences

• Allosteric Regulation 100%
• src Homology Domains 61%
• Pharmaceutical Preparations 27%
• Adenosine Triphosphate 26%
• Phosphotransferases 26%
• Catalysis 20%
• Molecular Dynamics Simulation 18%
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive 17%
• Hand Strength 17%
• Drug Discovery 17%
• Drug Resistance 15%
• Protein-Tyrosine Kinases 15%
• Catalytic Domain 15%
• Cell Survival 12%
• Mutation 9%
• Growth 8%

Engineering & Materials Science

• Chemical activation 60%
• Conformations 50%
• Adenosinetriphosphate 34%
• Cell growth 18%
• Drug Discovery 18%
• Catalysis 17%
• Docks 17%
• Molecular dynamics 15%
• Cells 13%
• Switches 9%
• Computer simulation 7%
• Experiments 4%

Chemistry

• Drug 35%
• Statistical Ensemble 26%
• Simulation 16%
• Tyrosine 12%
• Mutation 11%
• Flexibility 10%
• Molecular Dynamics 9%
• Dissociation 9%