@article{2d43c24382bd4fcb994b40b38c0767b1,
title = "Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control",
abstract = "Intensive pyrethroid use in insect control has led to resistance buildup among various pests. One alternative to battle this problem envisions the combined use of synergistically acting insecticidal compounds. Pyrethroids, scorpion α- and β-toxins, and brevetoxins bind to distinct receptor sites on voltage-gated sodium channels (NaChs) and modify their function. The binding affinity of scorpion α-toxins to locust, but not rat-brain NaChs, is allosterically increased by pyrethroids and by brevetoxin-1. Brevetoxin-1 also increases the binding of an excitatory β-toxin to insect NaChs. These results reveal differences between insect and mammalian NaChs and may be exploited in new strategies of insect control.",
keywords = "Allosteric effect, Insect control, Insect sodium channel, Pyrethroid, Scorpion toxin binding, Selective insecticide",
author = "Nicolas Gilles and Michael Gurevitz and Dalia Gordon",
note = "Funding Information: This research was supported in part by the United States-Israel Binational Agricultural Research and Development grant IS-3259-01 (D.G. and M.G.), and by the Israeli Science Foundation, grants 508/00 (D.G.) and 733/01 (M.G.). ",
year = "2003",
month = apr,
day = "10",
doi = "10.1016/S0014-5793(03)00226-6",
language = "אנגלית",
volume = "540",
pages = "81--85",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "1-3",
}