Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control

Nicolas Gilles, Michael Gurevitz, Dalia Gordon

Research output: Contribution to journalArticlepeer-review

Abstract

Intensive pyrethroid use in insect control has led to resistance buildup among various pests. One alternative to battle this problem envisions the combined use of synergistically acting insecticidal compounds. Pyrethroids, scorpion α- and β-toxins, and brevetoxins bind to distinct receptor sites on voltage-gated sodium channels (NaChs) and modify their function. The binding affinity of scorpion α-toxins to locust, but not rat-brain NaChs, is allosterically increased by pyrethroids and by brevetoxin-1. Brevetoxin-1 also increases the binding of an excitatory β-toxin to insect NaChs. These results reveal differences between insect and mammalian NaChs and may be exploited in new strategies of insect control.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalFEBS Letters
Volume540
Issue number1-3
DOIs
StatePublished - 10 Apr 2003

Keywords

  • Allosteric effect
  • Insect control
  • Insect sodium channel
  • Pyrethroid
  • Scorpion toxin binding
  • Selective insecticide

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