Allogeneic hematopoietic cell transplantation for adult patients with acute leukemia: The role of meta-analyses

Ron Ram*, Anat Gafter-Gvili, Ofer Shpilberg, Pia Raanani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In spite of decades of research in the field of allogeneic hematopoietic cell transplantation for the treatment of acute leukemia, controversies regarding the role of transplant still exist. These stem not only from contradictory results of different studies, but also from differences in the design and the strength of evidence of the various trials. Meta-analysis is considered the highest level of evidence and as such has the power to resolve clinical issues comparing between different treatment modalities. The aim of this review is to examine the contribution of meta-analyses to the establishment of the role of hematopoietic transplantation for acute leukemia and at the same time to highlight limitations and future directions.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalActa Haematologica
Volume125
Issue number1-2
DOIs
StatePublished - Dec 2010

Keywords

  • Allogeneic hematopoietic cell transplantation
  • Autologous stem cell transplant
  • Genetically randomized trials
  • Leukemia
  • Meta-analyses
  • Transplantation

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