TY - JOUR
T1 - Allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia
T2 - The BFM/IBFM/EBMT concepts
AU - BFM Study Group, the IBFM-Study Group and the Paediatric Disease Working Party of the EBMT
AU - Peters, C.
AU - Schrauder, A.
AU - Schrappe, M.
AU - von Stackelberg, A.
AU - Stary, J.
AU - Yaniv, I.
AU - Gadner, H.
AU - Klingebiel, T.
PY - 2005/3
Y1 - 2005/3
N2 - Children with high risk or relapsed acute lymphoblastic leukaemia (ALL) can benefit from allogeneic haematopoietic stem cell transplantation (SCT). To reduce transplantation-associated complications, the BFM study group, the IBFM study group and the PD-WP-EBMT initiated a prospective cooperative multicentre trail for paediatric ALL patients with an indication for allogeneic stem cell transplantation. Four-digit high-resolution HLA typing for all nonsibling donors, standardised GvHD prophylaxis and therapy, uniform conditioning regimen and minimum standards for supportive care should reduce not only treatment-related mortality but also ameliorate late effects for young patients. Furthermore, the prospective evaluation aims to assess the role of haematopoietic SCT in comparison to chemotherapy to enable valuable treatment recommendations for further decisions.
AB - Children with high risk or relapsed acute lymphoblastic leukaemia (ALL) can benefit from allogeneic haematopoietic stem cell transplantation (SCT). To reduce transplantation-associated complications, the BFM study group, the IBFM study group and the PD-WP-EBMT initiated a prospective cooperative multicentre trail for paediatric ALL patients with an indication for allogeneic stem cell transplantation. Four-digit high-resolution HLA typing for all nonsibling donors, standardised GvHD prophylaxis and therapy, uniform conditioning regimen and minimum standards for supportive care should reduce not only treatment-related mortality but also ameliorate late effects for young patients. Furthermore, the prospective evaluation aims to assess the role of haematopoietic SCT in comparison to chemotherapy to enable valuable treatment recommendations for further decisions.
KW - Acute lymphoblastic leukaemia
KW - Children
KW - Conditioning
KW - Donor
KW - Stem cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=18144362151&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1704835
DO - 10.1038/sj.bmt.1704835
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AN - SCOPUS:18144362151
SN - 0268-3369
VL - 35
SP - S9-S11
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
ER -
