Allogeneic haematopoietic cell transplantation for myelofibrosis: a real-life perspective

Malvi Savani, Rémy Dulery, Abdul Hamid Bazarbachi, Razan Mohty, Eolia Brissot, Florent Malard, Ali Bazarbachi, Arnon Nagler, Mohamad Mohty

Research output: Contribution to journalReview articlepeer-review

Abstract

Myelofibrosis (MF) is a clonal stem cell neoplasm with heterogeneous clinical phenotypes and well-established molecular drivers. Allogeneic haematopoietic stem cell transplantation (HSCT) offers an important curative treatment option for primary MF and post-essential thrombocythaemia/polycythaemia vera MF or secondary MF. With a disease course that varies from indolent to highly progressive, we are now able to stratify risk of mortality through various tools including patient-related clinical characteristics as well as molecular genetic profile. Owing to the high risk of mortality and morbidity associated with HSCT for patients with myelofibrosis, it is important to improve patient selection for transplant. Our primary goal is to comprehensively define our understanding of current practices including the role of Janus Kinase (JAK) inhibitors, to present the data behind transplantation before and after leukaemic transformation, and to introduce novel personalization of MF treatment with a proposed clinical-molecular prognostic model to help elucidate a timepoint optimal for consideration of HSCT.

Original languageEnglish
Pages (from-to)495-506
Number of pages12
JournalBritish Journal of Haematology
Volume195
Issue number4
DOIs
StatePublished - Nov 2021
Externally publishedYes

Keywords

  • allogeneic transplant
  • myelofibrosis
  • ruxolitinib
  • splenectomy

Fingerprint

Dive into the research topics of 'Allogeneic haematopoietic cell transplantation for myelofibrosis: a real-life perspective'. Together they form a unique fingerprint.

Cite this