TY - JOUR
T1 - Allergic reactions to measles-mumps-rubella (MMR) vaccine
AU - Levy, Y.
AU - Kornbrot, B.
AU - Danon, Y. L.
PY - 1998
Y1 - 1998
N2 - Forty-seven egg allergic children (age range: 1-12 years) received the first dose of measles-mumps-rubella (MMR) immunization after performing intradermal (ID) skin tests to MMR (1:100). None of the children, including seven with positive ID MMR skin tests who received the injection in small incremental doses, developed an immediate systemic reaction. One additional girl without egg allergy, was referred for the second dose of MMR immunization due to a past history of allergic reaction to the first dose. This time she had a positive MMR skin test and developed an immediate allergic reaction after receiving 1/10 of the dose (0.05 cc, injected subcutaneously). Specific IgE and IgG antibodies against gelatin, which is one of the constituents of the MMR vaccine, were demonstrated in this patient's serum. We conclude that MMR vaccine can be safely given to egg allergic children. Other allergenic components of the vaccine might be responsible for immediate allergic reactions attributed to egg-protein traces.
AB - Forty-seven egg allergic children (age range: 1-12 years) received the first dose of measles-mumps-rubella (MMR) immunization after performing intradermal (ID) skin tests to MMR (1:100). None of the children, including seven with positive ID MMR skin tests who received the injection in small incremental doses, developed an immediate systemic reaction. One additional girl without egg allergy, was referred for the second dose of MMR immunization due to a past history of allergic reaction to the first dose. This time she had a positive MMR skin test and developed an immediate allergic reaction after receiving 1/10 of the dose (0.05 cc, injected subcutaneously). Specific IgE and IgG antibodies against gelatin, which is one of the constituents of the MMR vaccine, were demonstrated in this patient's serum. We conclude that MMR vaccine can be safely given to egg allergic children. Other allergenic components of the vaccine might be responsible for immediate allergic reactions attributed to egg-protein traces.
KW - Egg-protein
KW - Immediate hypersensitivity
KW - MMR
UR - http://www.scopus.com/inward/record.url?scp=0032440047&partnerID=8YFLogxK
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AN - SCOPUS:0032440047
SN - 0899-5869
VL - 10
SP - 43
EP - 45
JO - Children's Hospital Quarterly
JF - Children's Hospital Quarterly
IS - 1
ER -
