Allergic reactions to measles-mumps-rubella (MMR) vaccine

Y. Levy*, B. Kornbrot, Y. L. Danon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Forty-seven egg allergic children (age range: 1-12 years) received the first dose of measles-mumps-rubella (MMR) immunization after performing intradermal (ID) skin tests to MMR (1:100). None of the children, including seven with positive ID MMR skin tests who received the injection in small incremental doses, developed an immediate systemic reaction. One additional girl without egg allergy, was referred for the second dose of MMR immunization due to a past history of allergic reaction to the first dose. This time she had a positive MMR skin test and developed an immediate allergic reaction after receiving 1/10 of the dose (0.05 cc, injected subcutaneously). Specific IgE and IgG antibodies against gelatin, which is one of the constituents of the MMR vaccine, were demonstrated in this patient's serum. We conclude that MMR vaccine can be safely given to egg allergic children. Other allergenic components of the vaccine might be responsible for immediate allergic reactions attributed to egg-protein traces.

Original languageEnglish
Pages (from-to)43-45
Number of pages3
JournalChildren's Hospital Quarterly
Issue number1
StatePublished - 1998
Externally publishedYes


  • Egg-protein
  • Immediate hypersensitivity
  • MMR


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