@article{cf28fb9af7fc4c41af1f12e95acfeeaa,
title = "Alcohol Drinks Induce Acute Lowering in Circulating l-Arginine in Obese and Type 2 Diabetic Subjects",
abstract = "Since low serum l-Arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested whether Arg and ADMA are affected by diet and physical activity in overweight/obese and T2DM subjects. We tested the effects on serum Arg and ADMA of single loads of dextrose, protein, fat, or alcohol (∼300 calories each); one episode of physical exercise; and 12 weeks of standard lifestyle modification (dietary and physical activity counseling). Alcohol drink was followed by ∼30% lowering in Arg. Arg and ADMA increased after a protein load but remained stable after glucose or fat load or 30 min of treadmill walk. Following 12 weeks of lifestyle modification, ADMA declined only in subjects achieving weight loss >5%. In conclusion, alcohol is a previously unrecognized acute suppressor of serum Arg. Lifestyle modification lowers ADMA in subjects who achieve weight loss >5%. Clinical Trial Registration Number: NCT04406402.",
keywords = "arginine, asymmetric dimethylarginine, diabetes mellitus, metabolic syndrome, obesity",
author = "Assaf Buch and Tali Ganz and Julio Wainstein and Suzan Gilad and Rona Limor and Gabi Shefer and Mona Boaz and Naftali Stern",
note = "Publisher Copyright: {\textcopyright} Copyright 2022, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2022.",
year = "2022",
month = jun,
day = "1",
doi = "10.1089/jmf.2021.0045",
language = "אנגלית",
volume = "25",
pages = "675--682",
journal = "Journal of Medicinal Food",
issn = "1096-620X",
publisher = "Mary Ann Liebert Inc.",
number = "6",
}