Alcohol Drinks Induce Acute Lowering in Circulating l-Arginine in Obese and Type 2 Diabetic Subjects

Assaf Buch, Tali Ganz, Julio Wainstein, Suzan Gilad, Rona Limor, Gabi Shefer, Mona Boaz, Naftali Stern*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Since low serum l-Arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested whether Arg and ADMA are affected by diet and physical activity in overweight/obese and T2DM subjects. We tested the effects on serum Arg and ADMA of single loads of dextrose, protein, fat, or alcohol (∼300 calories each); one episode of physical exercise; and 12 weeks of standard lifestyle modification (dietary and physical activity counseling). Alcohol drink was followed by ∼30% lowering in Arg. Arg and ADMA increased after a protein load but remained stable after glucose or fat load or 30 min of treadmill walk. Following 12 weeks of lifestyle modification, ADMA declined only in subjects achieving weight loss >5%. In conclusion, alcohol is a previously unrecognized acute suppressor of serum Arg. Lifestyle modification lowers ADMA in subjects who achieve weight loss >5%. Clinical Trial Registration Number: NCT04406402.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalJournal of Medicinal Food
Issue number6
StatePublished - 1 Jun 2022


FundersFunder number
Sagol Foundation for the Metabolic Syndrome Research Center


    • arginine
    • asymmetric dimethylarginine
    • diabetes mellitus
    • metabolic syndrome
    • obesity


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