AKR lymphoma malignancy variants differing at late phase of metastasis

M. Michowitz, O. Klein, Y. Sharabi, A. Siegal, J. Leibovici

Research output: Contribution to journalArticlepeer-review


The bilogical behaviour of two AKR lymphoma variants, the TAU-39 and TAU-38, of low (LM) and high (HM) malignancy, respectively, has previously been described. In the present study an attempt was made to determine the phase in the metastatic process in which these variants differ. Two types of findings suggest that the two variants differ in the late phase of the process; (a) no difference in the degree of invasiveness of the primary tumor to the surrounding tissues has been found between the two variants, both being highly invasive; (b) comparison of malignant behavior in the "spontaneous metastasis" versus the "experimental metastasis" tests showed a similar ranking of malignancy of the two variants.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalCancer Letters
Issue number1
StatePublished - 30 Jun 1990


  • AKR lymphoma
  • malignancy variants
  • metastasis phase


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