Airway bacterial colonization and serum C-reactive protein are associated with chronic obstructive pulmonary disease exacerbation following bronchoscopic lung volume reduction

Oren Fruchter*, Dror Rosengarten, Elad Goldberg, Haim Ben-Zvi, Ruth Tor, Mordechai R. Kramer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Stable chronic obstructive pulmonary disease (COPD) patients often have lower airway bacterial colonization (ABC) which may modulate exacerbation frequency. Data regarding the association between ABC and post-procedural COPD exacerbations following bronchoscopic lung volume reduction (BLVR) are scant. Objectives: Our aim was to explore the correlation among ABC, serum C-reactive protein (CRP) level and the risk of COPD exacerbation within a month following BLVR. Methods: Pre-procedure bronchoalveolar lavage (BAL) quantitative bacterial cultures and serum levels of CRP were evaluated in severe COPD patients (N = 70, mean FEV1 = 34.6%) before BLVR by polymeric lung sealant. Results: Colonization with potential pathogenic microorganism (PPM) was observed in 40 (57.1%) patients. Out of 28 patients (40%) who had COPD exacerbation within 30days of BLVR, 23 (82.1%) had PPM in BAL culture compared with only 14 (33.3%) out of 42 patients who had uneventful procedure (P = 0.0027). Serum CRP level was significantly higher in patients with exacerbation compared with those with no exacerbation (mean 47.8 ± 66.0mg/L vs 13.05 ± 27.7mg/L, respectively, P = 0.0063). The combination of CRP level above 3.12mg/L and PPM growth in BAL was observed in 89.2% of patients with exacerbation compared with only 52.3% of patients without exacerbation (P = 0.0031). Conclusions: ABC is common in severe COPD patients undergoing BLVR, and along with elevated CRP level both are associated with high risk of immediate post-procedural COPD exacerbation. These patients should be identified, carefully observed and possibly benefit from prophylactic microbiologically directed antibiotic treatment.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalClinical Respiratory Journal
Volume10
Issue number2
DOIs
StatePublished - 1 Mar 2016

Keywords

  • Bronchial colonization
  • COPD
  • Exacerbation
  • Lung volume reduction
  • Postoperative respiratory infection
  • Risk factors

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