Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients

Valery Istomin; Ester Sade; Zahava Grossman; Hagit Rudich; Orit Sofer; David Hassin

doi:10.1016/j.ejim.2004.11.002

Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients

Valery Istomin, Ester Sade, Zahava Grossman, Hagit Rudich, Orit Sofer, David Hassin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.

Original language	English
Pages (from-to)	531-533
Number of pages	3
Journal	European Journal of Internal Medicine
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/j.ejim.2004.11.002
State	Published - Dec 2004
Externally published	Yes

Keywords

Agranulocytosis
Human parvovirus B19 infection
Immunocompetent patients
Neutropenia
PCR

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10.1016/j.ejim.2004.11.002

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title = "Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients",

abstract = "In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.",

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AU - Istomin, Valery

AU - Sade, Ester

AU - Grossman, Zahava

AU - Rudich, Hagit

AU - Sofer, Orit

AU - Hassin, David

PY - 2004/12

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AB - In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.

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Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients

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