Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients

Valery Istomin, Ester Sade, Zahava Grossman, Hagit Rudich, Orit Sofer, David Hassin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.

Original languageEnglish
Pages (from-to)531-533
Number of pages3
JournalEuropean Journal of Internal Medicine
Issue number8
StatePublished - Dec 2004
Externally publishedYes


  • Agranulocytosis
  • Human parvovirus B19 infection
  • Immunocompetent patients
  • Neutropenia
  • PCR


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