TY - JOUR
T1 - Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients
AU - Istomin, Valery
AU - Sade, Ester
AU - Grossman, Zahava
AU - Rudich, Hagit
AU - Sofer, Orit
AU - Hassin, David
PY - 2004/12
Y1 - 2004/12
N2 - In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.
AB - In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.
KW - Agranulocytosis
KW - Human parvovirus B19 infection
KW - Immunocompetent patients
KW - Neutropenia
KW - PCR
UR - http://www.scopus.com/inward/record.url?scp=12844287060&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2004.11.002
DO - 10.1016/j.ejim.2004.11.002
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 15668091
AN - SCOPUS:12844287060
SN - 0953-6205
VL - 15
SP - 531
EP - 533
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
IS - 8
ER -
