Agonist-specific reverse regulation of muscarinic receptors by transition metal ions and guanine nucleotides

David Gurwitz, Mordechai Sokolovsky

Research output: Contribution to journalArticlepeer-review

Abstract

Transition metal ions, e.g. Mn2+, Ni2+ and Co2+ enhance in vitro agonist binding to muscarinic receptors in mouse cortex or hippocampus. This effect arises mainly from the conversion of low to high affinity binding sites. Binding properties of antagonists in these brain areas, as well as those of both agonists and antagonists of medulla-pons muscarinic receptors, are insensitive to these ions. The induced interconversion can be reversed by either of the following procedures: (i) removal of the ions; (ii) thermal exposure; (iii) addition of micromolar concentrations of guanine nucleotides.

Original languageEnglish
Pages (from-to)1296-1304
Number of pages9
JournalTopics in Catalysis
Volume96
Issue number3
DOIs
StatePublished - 1980

Fingerprint

Dive into the research topics of 'Agonist-specific reverse regulation of muscarinic receptors by transition metal ions and guanine nucleotides'. Together they form a unique fingerprint.

Cite this