Agmatine treatment is neuroprotective in rodent brain injury models

Gad M. Gilad; Khalil Salame; Jose M. Rabey; Varda H. Gilad

doi:10.1016/0024-3205(95)02274-0

Agmatine treatment is neuroprotective in rodent brain injury models

Gad M. Gilad^*, Khalil Salame, Jose M. Rabey, Varda H. Gilad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Agmatine is a naturally occurring guanidino compound, found in bacteria and plants, with several proposed nervous system-related functions suggestive of beneficial effects in central nervous system injury. Here evidence is presented that agmatine can exert potent neuroprotection in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. The cumulative evidence lead us to suggest that agmatine, a relatively nontoxic compound, be tried for potential therapeutic use after neurotrauma and in neurodegenerative disorders.

Original language	English
Pages (from-to)	PL41-PL46
Journal	Life Sciences
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(95)02274-0
State	Published - 1 Dec 1995
Externally published	Yes

Keywords

N-methyl-D-aspartate
cell death
ischemia
neuronal cultures
polyamines

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10.1016/0024-3205(95)02274-0

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title = "Agmatine treatment is neuroprotective in rodent brain injury models",

abstract = "Agmatine is a naturally occurring guanidino compound, found in bacteria and plants, with several proposed nervous system-related functions suggestive of beneficial effects in central nervous system injury. Here evidence is presented that agmatine can exert potent neuroprotection in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. The cumulative evidence lead us to suggest that agmatine, a relatively nontoxic compound, be tried for potential therapeutic use after neurotrauma and in neurodegenerative disorders.",

keywords = "N-methyl-D-aspartate, cell death, ischemia, neuronal cultures, polyamines",

author = "Gilad, {Gad M.} and Khalil Salame and Rabey, {Jose M.} and Gilad, {Varda H.}",

note = "Funding Information: Supported in part by a grant from the German-Israeli Foundation for Scientific Research and Development. The enzyme inhibitors, u-difluoromethylarginine and u-difluoromethylornithine were a gift from Marion Merrell Dow Research Institute, Strasbourg Research Center, Strasbourg, France.",

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AU - Salame, Khalil

AU - Rabey, Jose M.

AU - Gilad, Varda H.

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PY - 1995/12/1

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N2 - Agmatine is a naturally occurring guanidino compound, found in bacteria and plants, with several proposed nervous system-related functions suggestive of beneficial effects in central nervous system injury. Here evidence is presented that agmatine can exert potent neuroprotection in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. The cumulative evidence lead us to suggest that agmatine, a relatively nontoxic compound, be tried for potential therapeutic use after neurotrauma and in neurodegenerative disorders.

AB - Agmatine is a naturally occurring guanidino compound, found in bacteria and plants, with several proposed nervous system-related functions suggestive of beneficial effects in central nervous system injury. Here evidence is presented that agmatine can exert potent neuroprotection in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. The cumulative evidence lead us to suggest that agmatine, a relatively nontoxic compound, be tried for potential therapeutic use after neurotrauma and in neurodegenerative disorders.

KW - N-methyl-D-aspartate

KW - cell death

KW - ischemia

KW - neuronal cultures

KW - polyamines

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Agmatine treatment is neuroprotective in rodent brain injury models

Abstract

Keywords

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