Agmatine treatment is neuroprotective in rodent brain injury models

Gad M. Gilad*, Khalil Salame, Jose M. Rabey, Varda H. Gilad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Agmatine is a naturally occurring guanidino compound, found in bacteria and plants, with several proposed nervous system-related functions suggestive of beneficial effects in central nervous system injury. Here evidence is presented that agmatine can exert potent neuroprotection in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. The cumulative evidence lead us to suggest that agmatine, a relatively nontoxic compound, be tried for potential therapeutic use after neurotrauma and in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)PL41-PL46
JournalLife Sciences
Issue number2
StatePublished - 1 Dec 1995
Externally publishedYes


  • N-methyl-D-aspartate
  • cell death
  • ischemia
  • neuronal cultures
  • polyamines


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