Agitation and postdexamethasone cortisol levels in Alzheimer's disease

Brian A. Lawlor*, Gabriel Tsuboyama, Theresa Ryan, Richard C. Mohs, Bonnie M. Davis, Michael Davidson, Steven Gabriel, Kenneth L. Davis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical correlates of hypothalamic-pituitary-adrenal (HPA) functioning were examined in 29 patients with probable Alzheimer's disease. The 8:00 a.m. postdexamethasone cortisol levels of these patients were highly correlated with higher agitation scores but not with the degree of depressed mood or memory impairment. The possible neural basis for the association between hypercortisolism and behavioral disturbance in Alzheimer's disease warrants further exploration and replication.

Original languageEnglish
Pages (from-to)546-548
Number of pages3
JournalAmerican Journal of Psychiatry
Volume149
Issue number4
StatePublished - 1992
Externally publishedYes

Funding

FundersFunder number
National Institute on AgingP50AG005138

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