TY - JOUR
T1 - Aging affects transcranial magnetic modulation of hippocampal evoked potentials
AU - Levkovitz, Y.
AU - Segal, M.
N1 - Funding Information:
We would like to thank Dr. N. Grisaru for help with the TMS equipment. Supported by a grant from the Israel Center for Psychobiology in Israel and by the Abramson Family Foundation.
PY - 2001
Y1 - 2001
N2 - Transcranial magnetic stimulation (TMS) is being proposed as a method of choice for the treatment of clinical depression, yet its action in the brain is still not well understood. In previous studies we found that TMS has a long-term effect on reactivity of the hippocampus to perforant path stimulation. Since the efficacy of antidepressants is highly age-dependent, we studied possible age-related effects of TMS on hippocampal evoked responses. Young adult (3 months), aging (10 months) and aged (24-26 months) awake rats were subjected to daily TMS for one week, followed by measurements of several parameters of reactivity to perforant path stimulation in the anesthetized rat. TMS did not affect responses of the hippocampus to single perforant path stimulation, but reduced drastically paired-pulse and frequency dependent depression in the young and aging but not the old rats. Likewise, TMS increased LTP expression in the young but not the old rats, and reduced the efficacy of serotonin modulation of reactivity of the hippocampus, in the young but not the old rats. Thus, long term effects of chronic TMS on local GABAergic inhibition are highly age dependent.
AB - Transcranial magnetic stimulation (TMS) is being proposed as a method of choice for the treatment of clinical depression, yet its action in the brain is still not well understood. In previous studies we found that TMS has a long-term effect on reactivity of the hippocampus to perforant path stimulation. Since the efficacy of antidepressants is highly age-dependent, we studied possible age-related effects of TMS on hippocampal evoked responses. Young adult (3 months), aging (10 months) and aged (24-26 months) awake rats were subjected to daily TMS for one week, followed by measurements of several parameters of reactivity to perforant path stimulation in the anesthetized rat. TMS did not affect responses of the hippocampus to single perforant path stimulation, but reduced drastically paired-pulse and frequency dependent depression in the young and aging but not the old rats. Likewise, TMS increased LTP expression in the young but not the old rats, and reduced the efficacy of serotonin modulation of reactivity of the hippocampus, in the young but not the old rats. Thus, long term effects of chronic TMS on local GABAergic inhibition are highly age dependent.
KW - Aging rats
KW - Dentate gyrus
KW - GABAergic inhibition
KW - LTP
KW - Serotonin
KW - Transcranial magnetic stimulation
UR - https://www.scopus.com/pages/publications/0035115747
U2 - 10.1016/S0197-4580(00)00195-0
DO - 10.1016/S0197-4580(00)00195-0
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C2 - 11182475
AN - SCOPUS:0035115747
SN - 0197-4580
VL - 22
SP - 255
EP - 263
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 2
ER -