Aged versus young skin before and after transplantation onto nude mice

A. Gilhar, T. Pillar, M. David

Research output: Contribution to journalArticlepeer-review

Abstract

The behaviour of aged skin transplanted onto nude mice was investigated to determine whether the skin maintains its histological features. Split-thickness skin grafts obtained from the unexposed skin on the thighs of healthy aged and young volunteers were grafted onto nude mice. A significant difference between the mean thickness of young versus aged epidermis was noted before transplantation (P < 0.001). The epidermis of aged and young skin showed an increase in thickness following engraftment with a mean increase in epidermal thickness of 18.8% in the young (P < 0.01) and 142.5% in aged skin (P < 0.001). The number of blood vessels in the aged skin was significantly lower than in the young skin, but a remarkable increase was found post-transplantation. These findings indicate that part of the typical histological changes of unexposed aged skin are reversible.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalBritish Journal of Dermatology
Volume124
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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