Age-related normograms of serum antimüllerian hormone levels in a population of infertile women: A multicenter study

Benny Almog*, Fady Shehata, Sami Suissa, Hananel Holzer, Einat Shalom-Paz, Antonio La Marca, Shanthi Muttukrishna, Andrew Blazar, Richard Hackett, Scott M. Nelson, Joao Sabino Cunha-Filho, Talia Eldar-Geva, Ehud J. Margalioth, Nick Raine-Fenning, Kannamannadiar Jayaprakasan, Myvanwy McIlveen, Dorothea Wunder, Thomas Freour, Luciano G. Nardo, Juan BalaschJoana Peñarrubia, Jesper Smeenk, Christian Gnoth, Erhard Godehardt, Tsung Hsien Lee, Maw Sheng Lee, Ishai Levin, Ronni Gamzu, Togas Tulandi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To produce age-related normograms for serum antimüllerian hormone (AMH) level in infertile women without polycystic ovaries (non-PCO). Design: Retrospective cohort analysis. Setting: Fifteen academic reproductive centers. Patient(s): A total of 3,871 infertile women. Intervention(s): Blood sampling for AMH level. Main Outcome Measure(s): Serum AMH levels and correlation between age and different percentiles of AMH. Result(s): Age-related normograms for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles of AMH were produced. We found that the curves of AMH by age for the 3rd to 50th percentiles fit the model and appearance of linear relation, whereas the curves of >75th percentiles fit cubic relation. There were significant differences in AMH and FSH levels and in antral follicle count (AFC) among women aged 24-33 years, 34-38 years, and ≥39 years. Multivariate stepwise linear regression analysis of FSH, age, AFC, and the type of AMH kit as predictors of AMH level shows that all variables are independently associated with AMH level, in the following order: AFC, FSH, type of AMH kit, and age. Conclusion(s): Age-related normograms in non-PCO infertile women for the 3rd to 97th percentiles were produced. These normograms could provide a reference guide for the clinician to consult women with infertility. However, future validation with longitudinal data is still needed.

Original languageEnglish
Pages (from-to)2359-2363.e1
JournalFertility and Sterility
Volume95
Issue number7
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Antimüllerian hormone
  • age
  • normogram
  • ovarian reserve

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