TY - JOUR
T1 - Age-related normograms of serum antimüllerian hormone levels in a population of infertile women
T2 - A multicenter study
AU - Almog, Benny
AU - Shehata, Fady
AU - Suissa, Sami
AU - Holzer, Hananel
AU - Shalom-Paz, Einat
AU - La Marca, Antonio
AU - Muttukrishna, Shanthi
AU - Blazar, Andrew
AU - Hackett, Richard
AU - Nelson, Scott M.
AU - Cunha-Filho, Joao Sabino
AU - Eldar-Geva, Talia
AU - Margalioth, Ehud J.
AU - Raine-Fenning, Nick
AU - Jayaprakasan, Kannamannadiar
AU - McIlveen, Myvanwy
AU - Wunder, Dorothea
AU - Freour, Thomas
AU - Nardo, Luciano G.
AU - Balasch, Juan
AU - Peñarrubia, Joana
AU - Smeenk, Jesper
AU - Gnoth, Christian
AU - Godehardt, Erhard
AU - Lee, Tsung Hsien
AU - Lee, Maw Sheng
AU - Levin, Ishai
AU - Gamzu, Ronni
AU - Tulandi, Togas
PY - 2011/6
Y1 - 2011/6
N2 - Objective: To produce age-related normograms for serum antimüllerian hormone (AMH) level in infertile women without polycystic ovaries (non-PCO). Design: Retrospective cohort analysis. Setting: Fifteen academic reproductive centers. Patient(s): A total of 3,871 infertile women. Intervention(s): Blood sampling for AMH level. Main Outcome Measure(s): Serum AMH levels and correlation between age and different percentiles of AMH. Result(s): Age-related normograms for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles of AMH were produced. We found that the curves of AMH by age for the 3rd to 50th percentiles fit the model and appearance of linear relation, whereas the curves of >75th percentiles fit cubic relation. There were significant differences in AMH and FSH levels and in antral follicle count (AFC) among women aged 24-33 years, 34-38 years, and ≥39 years. Multivariate stepwise linear regression analysis of FSH, age, AFC, and the type of AMH kit as predictors of AMH level shows that all variables are independently associated with AMH level, in the following order: AFC, FSH, type of AMH kit, and age. Conclusion(s): Age-related normograms in non-PCO infertile women for the 3rd to 97th percentiles were produced. These normograms could provide a reference guide for the clinician to consult women with infertility. However, future validation with longitudinal data is still needed.
AB - Objective: To produce age-related normograms for serum antimüllerian hormone (AMH) level in infertile women without polycystic ovaries (non-PCO). Design: Retrospective cohort analysis. Setting: Fifteen academic reproductive centers. Patient(s): A total of 3,871 infertile women. Intervention(s): Blood sampling for AMH level. Main Outcome Measure(s): Serum AMH levels and correlation between age and different percentiles of AMH. Result(s): Age-related normograms for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles of AMH were produced. We found that the curves of AMH by age for the 3rd to 50th percentiles fit the model and appearance of linear relation, whereas the curves of >75th percentiles fit cubic relation. There were significant differences in AMH and FSH levels and in antral follicle count (AFC) among women aged 24-33 years, 34-38 years, and ≥39 years. Multivariate stepwise linear regression analysis of FSH, age, AFC, and the type of AMH kit as predictors of AMH level shows that all variables are independently associated with AMH level, in the following order: AFC, FSH, type of AMH kit, and age. Conclusion(s): Age-related normograms in non-PCO infertile women for the 3rd to 97th percentiles were produced. These normograms could provide a reference guide for the clinician to consult women with infertility. However, future validation with longitudinal data is still needed.
KW - Antimüllerian hormone
KW - age
KW - normogram
KW - ovarian reserve
UR - http://www.scopus.com/inward/record.url?scp=79956358262&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2011.02.057
DO - 10.1016/j.fertnstert.2011.02.057
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AN - SCOPUS:79956358262
SN - 0015-0282
VL - 95
SP - 2359-2363.e1
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 7
ER -