Age-related basement membrane thickening of the vocal cords in sudden infant death syndrome (SIDS)

Anat Shatz, Yehuda Hiss, Ilan Hammel, Baruch Arensburg, Sadik Variend

Research output: Contribution to journalArticlepeer-review

Abstract

Sudden infant death syndrome (SIDS) remains the leading cause of death in the Western world among infants between the ages of 1 month to 1 year. The diagnosis can only be established at autopsy, at which time no obvious or recognizable pathology is evident. A correlation between thickening of the basement membrane of the true vocal cords and the victim’s age was observed in all 51 larynges examined, whereas no such finding was detected in 82 larynges of infants who died of other causes. Thus, the data support the authors’ previous morphological results suggesting the use of basement membrane thickening as a marker of positive diagnosis of SIDS at autopsy. The possibility that an immune process may be associated with this syndrome merits further investigation and could prove to be of great importance.

Original languageEnglish
Pages (from-to)865-868
Number of pages4
JournalLaryngoscope
Volume104
Issue number7
DOIs
StatePublished - Jul 1994

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