Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos; Jan Lubinski; Henry T. Lynch; Susan L. Neuhausen; Parviz Ghadirian; Claudine Isaacs; Barbara Weber; Charmaine Kim-Sing; William D. Foulkes; Ruth Gershoni-Baruch; Peter Ainsworth; Eitan Friedman; Mary Daly; Judy E. Garber; Beth Karlan; Olufunmilayo I. Olopade; Nadine Tung; Howard M. Saal; Andrea Eisen; Michael Osborne; Hakan Olsson; Dawna Gilchrist; Ping Sun; Steven A. Narod

doi:10.1007/s10552-005-1724-1

Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos, Jan Lubinski, Henry T. Lynch, Susan L. Neuhausen, Parviz Ghadirian, Claudine Isaacs, Barbara Weber, Charmaine Kim-Sing, William D. Foulkes, Ruth Gershoni-Baruch, Peter Ainsworth, Eitan Friedman, Mary Daly, Judy E. Garber, Beth Karlan, Olufunmilayo I. Olopade, Nadine Tung, Howard M. Saal, Andrea Eisen, Michael OsborneHakan Olsson, Dawna Gilchrist, Ping Sun, Steven A. Narod^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene (n = 366 pairs). Information about age at menarche was derived from a questionnaire routinely administered to carriers of a mutation in either gene. Among women who carried a deleterious BRCA1 mutation, age at menarche was inversely associated with the risk of breast cancer (p trend = 0.0002). This association was not observed among BRCA2 mutation carriers (p trend = 0.49). Compared with BRCA1 carriers whose age at menarche was ≤11 years, women with a menarcheal age between 14 and 15 years old had a 54% reduction in risk (OR = 0.46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation.

Original language	English
Pages (from-to)	667-674
Number of pages	8
Journal	Cancer Causes and Control
Volume	16
Issue number	6
DOIs	https://doi.org/10.1007/s10552-005-1724-1
State	Published - Aug 2005
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health
National Cancer Institute	R01CA074415
Canadian Breast Cancer Research Alliance

Keywords

Age at menarche
BRCA1
BRCA2
Breast cancer
Case-control study
Reproductive modifiers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10552-005-1724-1

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Kotsopoulos, J., Lubinski, J., Lynch, H. T., Neuhausen, S. L., Ghadirian, P., Isaacs, C., Weber, B., Kim-Sing, C., Foulkes, W. D., Gershoni-Baruch, R., Ainsworth, P., Friedman, E., Daly, M., Garber, J. E., Karlan, B., Olopade, O. I., Tung, N., Saal, H. M., Eisen, A., ... Narod, S. A. (2005). Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Cancer Causes and Control, 16(6), 667-674. https://doi.org/10.1007/s10552-005-1724-1

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title = "Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers",

abstract = "Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene (n = 366 pairs). Information about age at menarche was derived from a questionnaire routinely administered to carriers of a mutation in either gene. Among women who carried a deleterious BRCA1 mutation, age at menarche was inversely associated with the risk of breast cancer (p trend = 0.0002). This association was not observed among BRCA2 mutation carriers (p trend = 0.49). Compared with BRCA1 carriers whose age at menarche was ≤11 years, women with a menarcheal age between 14 and 15 years old had a 54% reduction in risk (OR = 0.46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation.",

keywords = "Age at menarche, BRCA1, BRCA2, Breast cancer, Case-control study, Reproductive modifiers",

author = "Joanne Kotsopoulos and Jan Lubinski and Lynch, {Henry T.} and Neuhausen, {Susan L.} and Parviz Ghadirian and Claudine Isaacs and Barbara Weber and Charmaine Kim-Sing and Foulkes, {William D.} and Ruth Gershoni-Baruch and Peter Ainsworth and Eitan Friedman and Mary Daly and Garber, {Judy E.} and Beth Karlan and Olopade, {Olufunmilayo I.} and Nadine Tung and Saal, {Howard M.} and Andrea Eisen and Michael Osborne and Hakan Olsson and Dawna Gilchrist and Ping Sun and Narod, {Steven A.}",

note = "Funding Information: Supported by a grant from the Canadian Breast Cancer Research Alliance. Susan L. Neuhausen is supported by a grant from the National Institutes of Health (NIH CA74415). We thank B. Rosen, G. Rennert, C. Eng, J. McLennan, W. McKinnon, M. Wood, S. Merajver, D. Fishman, D. Provencher, J. Weitzel, G. Evans, P. Moller, W.S. Meschino, E. Lemire and T. Wagner for submission of data on their patients.",

year = "2005",

month = aug,

doi = "10.1007/s10552-005-1724-1",

language = "אנגלית",

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journal = "Cancer Causes and Control",

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Kotsopoulos, J, Lubinski, J, Lynch, HT, Neuhausen, SL, Ghadirian, P, Isaacs, C, Weber, B, Kim-Sing, C, Foulkes, WD, Gershoni-Baruch, R, Ainsworth, P, Friedman, E, Daly, M, Garber, JE, Karlan, B, Olopade, OI, Tung, N, Saal, HM, Eisen, A, Osborne, M, Olsson, H, Gilchrist, D, Sun, P & Narod, SA 2005, 'Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers', Cancer Causes and Control, vol. 16, no. 6, pp. 667-674. https://doi.org/10.1007/s10552-005-1724-1

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T1 - Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

AU - Kotsopoulos, Joanne

AU - Lubinski, Jan

AU - Lynch, Henry T.

AU - Neuhausen, Susan L.

AU - Ghadirian, Parviz

AU - Isaacs, Claudine

AU - Weber, Barbara

AU - Kim-Sing, Charmaine

AU - Foulkes, William D.

AU - Gershoni-Baruch, Ruth

AU - Ainsworth, Peter

AU - Friedman, Eitan

AU - Daly, Mary

AU - Garber, Judy E.

AU - Karlan, Beth

AU - Olopade, Olufunmilayo I.

AU - Tung, Nadine

AU - Saal, Howard M.

AU - Eisen, Andrea

AU - Osborne, Michael

AU - Olsson, Hakan

AU - Gilchrist, Dawna

AU - Sun, Ping

AU - Narod, Steven A.

N1 - Funding Information: Supported by a grant from the Canadian Breast Cancer Research Alliance. Susan L. Neuhausen is supported by a grant from the National Institutes of Health (NIH CA74415). We thank B. Rosen, G. Rennert, C. Eng, J. McLennan, W. McKinnon, M. Wood, S. Merajver, D. Fishman, D. Provencher, J. Weitzel, G. Evans, P. Moller, W.S. Meschino, E. Lemire and T. Wagner for submission of data on their patients.

PY - 2005/8

Y1 - 2005/8

N2 - Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene (n = 366 pairs). Information about age at menarche was derived from a questionnaire routinely administered to carriers of a mutation in either gene. Among women who carried a deleterious BRCA1 mutation, age at menarche was inversely associated with the risk of breast cancer (p trend = 0.0002). This association was not observed among BRCA2 mutation carriers (p trend = 0.49). Compared with BRCA1 carriers whose age at menarche was ≤11 years, women with a menarcheal age between 14 and 15 years old had a 54% reduction in risk (OR = 0.46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation.

AB - Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene (n = 366 pairs). Information about age at menarche was derived from a questionnaire routinely administered to carriers of a mutation in either gene. Among women who carried a deleterious BRCA1 mutation, age at menarche was inversely associated with the risk of breast cancer (p trend = 0.0002). This association was not observed among BRCA2 mutation carriers (p trend = 0.49). Compared with BRCA1 carriers whose age at menarche was ≤11 years, women with a menarcheal age between 14 and 15 years old had a 54% reduction in risk (OR = 0.46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation.

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KW - BRCA2

KW - Breast cancer

KW - Case-control study

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Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Abstract

Funding

Keywords

UN SDGs

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