@article{9c5d6e985b1045f98c6009eee28ef792,
title = "African-specific variability in the acetylcholine muscarinic receptor M4: Association with cocaine and heroin addiction",
abstract = "Aim: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. Patients & methods: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. Results: Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (Pcorrected = 0.047). CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia. CHRM4 SNP rs2229163 is in strong linkage disequilibrium with several African-specific SNPs in DGKZ and AMBRA1. Conclusion: Cholinergic receptors' variants may contribute to drug addiction and have a potential role as pharmacogenetic markers.",
keywords = "African ancestry, CHRM4, cholinergic receptors, cocaine addiction, opioid addiction",
author = "Orna Levran and Matthew Randesi and Einat Peles and {Correa Da Rosa}, Joel and Jurg Ott and John Rotrosen and Miriam Adelson and Kreek, {Mary Jeanne}",
note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",
year = "2016",
month = jun,
doi = "10.2217/pgs-2016-0028",
language = "אנגלית",
volume = "17",
pages = "995--1003",
journal = "Pharmacogenomics",
issn = "1462-2416",
publisher = "Taylor and Francis Ltd.",
number = "9",
}
