Aeruginosins from a microcystis sp. bloom material collected in Varanasi, India

Shira Elkobi-Peer, Rahul Kunwar Singh, Tribhuban Mohan Mohapatra, Shree Prakash Tiwari, Shmuel Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Two novel biologically active short peptides, aeruginosins IN608 and IN652, were isolated from the cyanobacterium Microcystis sp. strain BHU006, which was collected from Durgakund water reservoir in Varanasi, India. Aeruginosins IN608 and IN652 are linear modified peptides containing four building blocks, one of which is the arogenate-derived modified amino acid 2-carboxy-6- hydroxyoctahydroindole. Aeruginosin IN608 and aeruginosin IN652 inhibit the activity of the proteolytic enzyme trypsin with IC50's of 4.3 and 4.1 μM, respectively.

Original languageEnglish
Pages (from-to)1187-1190
Number of pages4
JournalJournal of Natural Products
Volume76
Issue number6
DOIs
StatePublished - 28 Jun 2013

Funding

FundersFunder number
Indian Council of Medical Research45/98/PHA/BMS

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