TY - JOUR
T1 - Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection
AU - Engemann, John J.
AU - Carmeli, Yehuda
AU - Cosgrove, Sara E.
AU - Fowler, Vance G.
AU - Bronstein, Melissa Z.
AU - Trivette, Sharon L.
AU - Briggs, Jane P.
AU - Sexton, Daniel J.
AU - Kaye, Keith S.
N1 - Funding Information:
Financial support: Unrestricted educational grant from Aventis Pharmaceuticals, fellowship from the Agency for Healthcare Research and Quality (to J.J.E.), and National Institutes of Health (grant AI-01647; to V.G.F.).
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Data for 479 patients were analyzed to assess the impact of methicillin resistance on the outcomes of patients with Staphylococcus aureus surgical site infections (SSIs). Patients infected with methicillin-resistant S. aureus (MRSA) had a greater 90-day mortality rate than did patients infected with methicillin-susceptible S. aureus (MSSA; adjusted odds ratio, 3.4; 95% confidence interval, 1.5-7.2). Patients infected with MRSA had a greater duration of hospitalization after infection (median additional days, 5; P<.001), although this was not significant on multivariate analysis (P = .11). Median hospital charges were $29,455 for control subjects, $52,791 for patients with MSSA SSI, and $92,363 for patients with MRSA SSI (P<.001 for all group comparisons). Patients with MRSA SSI had a 1.19-fold increase in hospital charges (P = .03) and had mean attributable excess charges of $13,901 per SSI compared with patients who had MSSA SSIs. Methicillin resistance is independently associated with increased mortality and hospital charges among patients with S. aureus SSI.
AB - Data for 479 patients were analyzed to assess the impact of methicillin resistance on the outcomes of patients with Staphylococcus aureus surgical site infections (SSIs). Patients infected with methicillin-resistant S. aureus (MRSA) had a greater 90-day mortality rate than did patients infected with methicillin-susceptible S. aureus (MSSA; adjusted odds ratio, 3.4; 95% confidence interval, 1.5-7.2). Patients infected with MRSA had a greater duration of hospitalization after infection (median additional days, 5; P<.001), although this was not significant on multivariate analysis (P = .11). Median hospital charges were $29,455 for control subjects, $52,791 for patients with MSSA SSI, and $92,363 for patients with MRSA SSI (P<.001 for all group comparisons). Patients with MRSA SSI had a 1.19-fold increase in hospital charges (P = .03) and had mean attributable excess charges of $13,901 per SSI compared with patients who had MSSA SSIs. Methicillin resistance is independently associated with increased mortality and hospital charges among patients with S. aureus SSI.
UR - http://www.scopus.com/inward/record.url?scp=0037371388&partnerID=8YFLogxK
U2 - 10.1086/367653
DO - 10.1086/367653
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C2 - 12594640
AN - SCOPUS:0037371388
SN - 1058-4838
VL - 36
SP - 592
EP - 598
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -
