TY - JOUR
T1 - Advances in understanding and management of IgG4-related ophthalmic disease
AU - Lai, Kenneth Ka Hei
AU - Ang, Terence Wee Xiang
AU - Cheuk, Wah
AU - Kwok, Angie
AU - Lin, Ming
AU - Lustig, Yael
AU - Selva, Dinesh
AU - Ben Simon, Guy
AU - Xing, Yue
AU - Xu, Zhi Hui
AU - Yang, Hua Sheng
AU - Chong, Kelvin Kam Lung
AU - Yuen, Hunter Kwok Lai
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/9/1
Y1 - 2024/9/1
N2 - Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an emerging, immune-mediated fibroinflammatory orbital disease, characterized by tumefactive lesions with noticeable IgG4+ plasma cell infiltration and distinctive pathohistological features. This disease is often associated with elevated serum IgG4 concentrations. IgG4-ROD may affect any ophthalmic tissues, particularly the lacrimal gland, extraocular muscles, and trigeminal nerves. Although the exact pathogenic role of IgG4 antibodies remains unclear, B-cell depleting agents have been reported to be an effective treatment. The diverse clinical manifestations of IgG4-ROD complicate diagnosis, and without prompt treatment, visual-threatening complications such as optic neuropathy may arise. Recent advances in understanding and managing IgG4-ROD have revolutionized the diagnosis and treatment of this emerging disease. This review article aims to provide a comprehensive overview of the latest advancements in the field of IgG4-ROD.
AB - Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an emerging, immune-mediated fibroinflammatory orbital disease, characterized by tumefactive lesions with noticeable IgG4+ plasma cell infiltration and distinctive pathohistological features. This disease is often associated with elevated serum IgG4 concentrations. IgG4-ROD may affect any ophthalmic tissues, particularly the lacrimal gland, extraocular muscles, and trigeminal nerves. Although the exact pathogenic role of IgG4 antibodies remains unclear, B-cell depleting agents have been reported to be an effective treatment. The diverse clinical manifestations of IgG4-ROD complicate diagnosis, and without prompt treatment, visual-threatening complications such as optic neuropathy may arise. Recent advances in understanding and managing IgG4-ROD have revolutionized the diagnosis and treatment of this emerging disease. This review article aims to provide a comprehensive overview of the latest advancements in the field of IgG4-ROD.
KW - IgG4-related disease
KW - IgG4-related ophthalmic disease
KW - Malignancy
UR - http://www.scopus.com/inward/record.url?scp=85207019234&partnerID=8YFLogxK
U2 - 10.1016/j.apjo.2024.100101
DO - 10.1016/j.apjo.2024.100101
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C2 - 39326526
AN - SCOPUS:85207019234
SN - 2162-0989
VL - 13
JO - Asia-Pacific Journal of Ophthalmology
JF - Asia-Pacific Journal of Ophthalmology
IS - 5
M1 - 100101
ER -