Advances in Microbial Biofilm Prevention on Indwelling Medical Devices with Emphasis on Usage of Acoustic Energy

Naama Dror, Mathilda Mandel, Zadik Hazan, Gad Lavie*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Microbial biofilms are a major impediment to the use of indwelling medical devices, generating device-related infections with high morbidity and mortality. Major efforts directed towards preventing and eradicating the biofilm problem face difficulties because biofilms protect themselves very effectively by producing a polysaccharide coating, reducing biofilm sensitivity to antimicrobial agents. Techniques applied to combating biofilms have been primarily chemical. These have met with partial and limited success rates, leading to current trends of eradicating biofilms through physico-mechanical strategies. Here we review the different approaches that have been developed to control biofilm formation and removal, focusing on the utilization of acoustic energy to achieve these objectives.

Original languageEnglish
Pages (from-to)2538-2554
Number of pages17
JournalSensors
Volume9
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • Acoustic energy
  • Anti-microbial agents
  • Biofilm prevention
  • Biofilms
  • Ultrasonication

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