TY - JOUR
T1 - Advances in antibody-mediated immunity against Mycobacterium tuberculosis
T2 - Implications for a novel vaccine strategy
AU - Glatman-Freedman, Aharona
N1 - Funding Information:
Many thanks to Drs. Arturo Casadevall, Joshua Nosanchuk and Bettina Fries for critical reading of the manuscript and many valuable suggestions and discussions. The author is supported by National Institute of Health (NIH) Grants AI001691 and AI053192.
PY - 2003/10/24
Y1 - 2003/10/24
N2 - Cell-mediated immunity is considered to be the major component of the host response against Mycobacterium tuberculosis, whereas antibody-mediated immunity historically has been considered inconsequential. In recent years, studies from several groups have challenged the traditional dogma and demonstrated that monoclonal antibodies can modify various aspects of mycobacterial infections. This review describes the experimental evidence supporting a role for antibodies in defense against mycobacterial infections and outlines future challenges to the field of antibody-mediated immunity against M. tuberculosis, with particular emphasis on the implications of these findings for a novel vaccine strategy.
AB - Cell-mediated immunity is considered to be the major component of the host response against Mycobacterium tuberculosis, whereas antibody-mediated immunity historically has been considered inconsequential. In recent years, studies from several groups have challenged the traditional dogma and demonstrated that monoclonal antibodies can modify various aspects of mycobacterial infections. This review describes the experimental evidence supporting a role for antibodies in defense against mycobacterial infections and outlines future challenges to the field of antibody-mediated immunity against M. tuberculosis, with particular emphasis on the implications of these findings for a novel vaccine strategy.
KW - Antibody-mediated immunity
KW - Monoclonal antibody
KW - Mycobacterium tuberculosis
KW - Mycobacterium tuberculosis vaccine
UR - http://www.scopus.com/inward/record.url?scp=0141526407&partnerID=8YFLogxK
U2 - 10.1016/S0928-8244(03)00172-X
DO - 10.1016/S0928-8244(03)00172-X
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C2 - 14556990
AN - SCOPUS:0141526407
SN - 0928-8244
VL - 39
SP - 9
EP - 16
JO - FEMS Immunology and Medical Microbiology
JF - FEMS Immunology and Medical Microbiology
IS - 1
ER -
