TY - JOUR
T1 - Advanced strategies in immune modulation of cancer using lipid-based nanoparticles
AU - Mizrahy, Shoshy
AU - Hazan-Halevy, Inbal
AU - Landesman-Milo, Dalit
AU - Ng, Brandon D.
AU - Peer, Dan
N1 - Publisher Copyright:
© 2017 Mizrahy, Hazan-Halevy, Landesman-Milo, Ng and Peer.
PY - 2017/2/6
Y1 - 2017/2/6
N2 - Immunotherapy has a great potential in advancing cancer treatment, especially in light of recent discoveries and therapeutic interventions that lead to complete response in specific subgroups of melanoma patients. By using the body's own immune system, it is possible not only to specifically target and eliminate cancer cells while leaving healthy cells unharmed but also to elicit long-term protective response. Despite the promise, current immunotherapy is limited and fails in addressing all tumor types. This is probably due to the fact that a single treatment strategy is not sufficient in overcoming the complex antitumor immunity. The use of nanoparticle-based system for immunotherapy is a promising strategy that can simultaneously target multiple pathways with the same kinetics to enhance antitumor response. Here, we will highlight the recent advances in the field of cancer immunotherapy that utilize lipid-based nanoparticles as delivery vehicles and address the ongoing challenges and potential opportunities.
AB - Immunotherapy has a great potential in advancing cancer treatment, especially in light of recent discoveries and therapeutic interventions that lead to complete response in specific subgroups of melanoma patients. By using the body's own immune system, it is possible not only to specifically target and eliminate cancer cells while leaving healthy cells unharmed but also to elicit long-term protective response. Despite the promise, current immunotherapy is limited and fails in addressing all tumor types. This is probably due to the fact that a single treatment strategy is not sufficient in overcoming the complex antitumor immunity. The use of nanoparticle-based system for immunotherapy is a promising strategy that can simultaneously target multiple pathways with the same kinetics to enhance antitumor response. Here, we will highlight the recent advances in the field of cancer immunotherapy that utilize lipid-based nanoparticles as delivery vehicles and address the ongoing challenges and potential opportunities.
KW - Cancer immunotherapy
KW - Cancer vaccines
KW - Lipid nanoparticles
KW - SiRNA therapeutic
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85014336496&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2017.00069
DO - 10.3389/fimmu.2017.00069
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C2 - 28220118
AN - SCOPUS:85014336496
SN - 1664-3224
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - FEB
M1 - 69
ER -